Orderly nucleic acid aggregates by electrostatic self-assembly in single cells for miRNA detection and visualizing
Literature Information
Publication Date
2016-03-29
DOI
10.1039/C6AN00160B
Impact Factor
4.616
Authors
Yuanyuan Wang, Zhaopeng Yu, Zhen Zhang, Shusheng Zhang
View Original
Abstract
Orderly nucleic acid aggregates (ONAAs) self-assembled on mesoporous silica nanoparticles (MSNs) with positively charged aminopropyl groups (PC) were firstly developed. Interestingly, a novel electrostatic DNA self-assembly could realize hybridization chain reaction (HCR) on the surface of PCMSNs in single cells. Significantly, a non-destructive amplification strategy based on ONAAs-PCMSNs was successfully developed for miRNA detection and in situ imaging by the prominent and agminated fluorescence-bright spots in living cells.
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Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
653
Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
6-Butyl-2-(2,4-difluorophenyl)-1,3,6,2-dioxazaborocane
CAS Number:
1190988-98-7
Molecular Formula:
C14H20BF2NO2
tert-Butyl 4-chloro-5-methoxypyridin-3-ylcarbamate
CAS Number:
1045858-17-0
Molecular Formula:
C11H15ClN2O3
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