A remarkable solvent effect of fluorinated alcohols on transition metal catalysed C–H functionalizations
Literature Information
Publication Date
2016-02-02
DOI
10.1039/C5QO00398A
Impact Factor
5.281
Authors
J. Wencel-Delord, F. Colobert
View Original
Abstract
Fluorinated solvents like 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) and trifluoroethanol (TFE) have recently emerged as a remarkable synthetic solution allowing challenging C–H activation reactions. A beneficial effect of these solvents on reactivity, as well as site- and stereoselectivity of various direct functionalization reactions has been observed. Moreover, several catalytic systems specifically require such fluorinated medium. This Highlight is devoted to showcasing the exceptional potential of fluorinated alcohols in the C–H activation field.
Recommended Journals
New Journal of Chemistry
Russian Journal of Bioorganic Chemistry
Journal of Natural Medicines
Russian Journal of Coordination Chemistry
Russian Journal of General Chemistry
Crystallography Reports
Saudi Pharmaceutical Journal
Current Opinion in Colloid & Interface Science
Organic Process Research & Development
Russian Journal of Organic Chemistry
Related Literature
Controlling micro-phase separation in semi-crystalline/amorphous conjugated block copolymers
Lianshan Li, Zhiyuan Tian, Zhiyong Tang
2014-05-21
Communication
DOI: 10.1039/C4PY00498A
Rapid, semi-automated convergent synthesis of low generation triazine dendrimers using microwave assisted reactions
Alan E. Enciso, Zachary M. Abid, Eric E. Simanek
2014-04-15
Paper
DOI: 10.1039/C4PY00349G
Polythiol copolymers with precise architectures: a platform for functional materials
Morgane Le Neindre, Renaud Nicolaÿ
2014-06-03
Review Article
DOI: 10.1039/C4PY00293H
DNA molecular recognition of intercalators affects aggregation of a thermoresponsive polymer
Yuuki Sugawara, Takanori Tamaki, Takeo Yamaguchi
2014-05-07
Communication
DOI: 10.1039/C4PY00600C
Switch on/off microcapsules for controllable photosensitive drug release in a ‘release-cease-recommence’ mode
Hang Lin, Wang Xiao, Si-Yong Qin, Si-Xue Cheng, Xian-Zheng Zhang
2014-05-15
Communication
DOI: 10.1039/C4PY00564C
How does a tiny terminal alkynyl end group drive fully hydrophilic homopolymers to self-assemble into multicompartment vesicles and flower-like complex particles?
Tingting Liu, Wei Tian, Yunqing Zhu, Yang Bai, Hongxia Yan, Jianzhong Du
2014-05-06
Paper
DOI: 10.1039/C4PY00501E
Enhanced performance for organic bulk heterojunction solar cells by cooperative assembly of ter(ethylene oxide) pendants
Lie Chen, Shaojie Tian
2014-03-11
Paper
DOI: 10.1039/C4PY00095A
You might also like
Compound Q&A
What is Ethyl 3-cyclohexylpropanoate (CAS: 10094-36-7)?
Ethyl 3-cyclohexylpropanoate is a clear, colorless to light yellow liquid with a...
10094-36-7Ethyl 3-cyclohexylpr...
Compound Q&A
How should waste containing 2-(Hydroxymethyl)-5-(methoxycarbonyl)-6-methyl-4-(2-nitrophenyl)nicotinic acid (CAS: 34783-31-8) be handled?
Waste containing 2-(Hydroxymethyl)-5-(methoxycarbonyl)-6-methyl-4-(2-nitrophenyl...
34783-31-82-(Hydroxymethyl)-5-...
Compound Q&A
How should waste containing 2,4,6-Tris(pentafluoroethyl)-1,3,5-triazine (CAS: 858-46-8) be handled?
Waste containing 2,4,6-Tris(pentafluoroethyl)-1,3,5-triazine (CAS: 858-46-8) sho...
858-46-82,4,6-Tris(pentafluo...
Compound Q&A
What precautions should be taken when handling Chloroac-nle-oh (CAS: 56787-36-1)?
When handling Chloroac-nle-oh (CAS: 56787-36-1), it is essential to wear appropr...
56787-36-1Chloroac-nle-oh
Compound Q&A
What industries use Ethyl 6-phenylimidazo[2,1-b][1,3]thiazole-3-carboxylate (CAS: 752244-05-6)?
Ethyl 6-phenylimidazo[2,1-b][1,3]thiazole-3-carboxylate is primarily used in the...
752244-05-6Ethyl 6-phenylimidaz...
Compound Q&A
Are there alternatives to alpha-(2-Bromophenyl)benzylamine (CAS: 55095-15-3) in synthesis?
Alternatives to alpha-(2-Bromophenyl)benzylamine (CAS: 55095-15-3) in synthesis ...
55095-15-3alpha-(2-Bromophenyl...
Compound Q&A
How should waste containing 2-Chloro-5-methoxypyridine (CAS: 139585-48-1) be handled?
Waste containing 2-Chloro-5-methoxypyridine (CAS: 139585-48-1) should be managed...
139585-48-12-Chloro-5-methoxypy...
Compound Q&A
What industries use 1-(4-Methoxyphenyl)-2,5-dimethyl-1H-pyrrole (CAS: 5044-27-9)?
1-(4-Methoxyphenyl)-2,5-dimethyl-1H-pyrrole (CAS: 5044-27-9) is used in various ...
5044-27-91-(4-Methoxyphenyl)-...
Compound Q&A
Are there alternatives to 3-Bromo-5-(N-Boc)aminomethylisoxazole (CAS: 903131-45-3) in synthesis?
There are alternative reagents and compounds that can be used in the synthesis o...
903131-45-33-Bromo-5-(N-Boc)ami...
Compound Q&A
What is Tungsten(IV) oxide (CAS: 12036-22-5)?
Tungsten(IV) oxide, also known as tungsten dioxide, is a chemical compound with ...
12036-22-5Tungsten(IV) oxide
Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.