Interaction of C60 fullerenes with asymmetric and curved lipid membranes: a molecular dynamics study

Literature Information

Publication Date 2015-11-16
DOI 10.1039/C5CP05838D
Impact Factor 3.676
Authors

Yevhen K. Cherniavskyi, Christophe Ramseyer, Semen O. Yesylevskyy


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Abstract

Interaction of fullerenes with asymmetric and curved DOPC/DOPS bicelles is studied by means of coarse-grained molecular dynamics simulations. The effects caused by asymmetric lipid composition of the membrane leaflets and the curvature of the membrane are analyzed. It is shown that the aggregates of fullerenes prefer to penetrate into the membrane in the regions of the moderately positive mean curvature. Upon penetration into the hydrophobic core of the membrane fullerenes avoid the regions of the extreme positive or the negative curvature. Fullerenes increase the ordering of lipid tails, which are in direct contact with them, but do not influence other lipids significantly. Our data suggest that the effects of the membrane curvature should be taken into account in the studies concerning permeability of the membranes to fullerenes and fullerene-based drug delivery systems.

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Contents list

Front/Back Matter

DOI: 10.1039/D0PY90079F

Contents list

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DOI: 10.1039/D0PY90068K

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Back cover

Cover

DOI: 10.1039/D0PY90089C

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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
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