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Applications of coherent Raman scattering microscopies to clinical and biological studies
Literature Information
Publication Date
2015-03-17
DOI
10.1039/C5AN00178A
Impact Factor
4.616
Authors
Iwan W. Schie, Christoph Krafft
View Original
Abstract
Coherent anti-Stokes Raman scattering (CARS) microscopy and stimulated Raman scattering (SRS) microscopy are two nonlinear optical imaging modalities that are at the frontier of label-free and chemical specific biological and clinical diagnostics. The applications of coherent Raman scattering (CRS) microscopies are multifold, ranging from investigation of basic aspects of cell biology to the label-free detection of pathologies. This review summarizes recent progress of biological and clinical applications of CRS between 2008 and 2014, covering applications such as lipid droplet research, single cell analysis, tissue imaging and multiphoton histopathology of atherosclerosis, myelin sheaths, skin, hair, pharmaceutics, and cancer and surgical margin detection.
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