Applications of coherent Raman scattering microscopies to clinical and biological studies

Literature Information

Publication Date 2015-03-17
DOI 10.1039/C5AN00178A
Impact Factor 4.616
Authors

Iwan W. Schie, Christoph Krafft


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Abstract

Coherent anti-Stokes Raman scattering (CARS) microscopy and stimulated Raman scattering (SRS) microscopy are two nonlinear optical imaging modalities that are at the frontier of label-free and chemical specific biological and clinical diagnostics. The applications of coherent Raman scattering (CRS) microscopies are multifold, ranging from investigation of basic aspects of cell biology to the label-free detection of pathologies. This review summarizes recent progress of biological and clinical applications of CRS between 2008 and 2014, covering applications such as lipid droplet research, single cell analysis, tissue imaging and multiphoton histopathology of atherosclerosis, myelin sheaths, skin, hair, pharmaceutics, and cancer and surgical margin detection.

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