Dual stimuli-responsive supramolecular hydrogel of bionanoparticles and hyaluronan

Literature Information

Publication Date 2014-08-07
DOI 10.1039/C4PY00819G
Impact Factor 5.582
Authors

Limin Chen, Xia Zhao, Yuan Lin, Zhaohui Su


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Abstract

We report here the synthesis of a light- and chemical-responsive supramolecular hydrogel of bacteriophage M13 and hyaluronan locked by the molecular recognition between β-cyclodextrin and trans-azobenzene moieties. Compared to rod-like tobacco mosaic virus (TMV), the filamentous bacteriophage M13 with higher aspect ratio and more flexible structure formed a much more robust hydrogel with hyaluronan, which was confirmed by the inversion test and rheological measurement. The resulting M13 hydrogel showed sol–gel transition behaviours induced by either photo-irradiation or competitive host or guest molecules. Moreover, cells could be facilely encapsulated and delivered using this supramolecular hydrogel with great cell viability.

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