![2-[({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)methyl]isonicotinic acid structure](https://static.chemtradehub.com/structs/473/473924-63-9-973b.webp "2-[({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)methyl]isonicotinic acid structure")
2-[({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)methyl]isonicotinic acid
CAS Number:
473924-63-9
Molecular Formula:
C12H16N2O4
Pluronic L61 as a long-circulating modifier for enhanced liposomal delivery of cancer drugs
Literature Information
Publication Date
2013-03-27
DOI
10.1039/C3PY00042G
Impact Factor
5.582
Authors
Ergang Liu, Xiaoyi Sun, Pengyu Huang, Hao Long, Hua Wang, Xin Yu, Caihong Zheng
View Original
Abstract
Pluronic copolymer L61 was found to possess a stealth function for liposomal drug delivery, comparing favorably to PEG. The liposomes modified with 0.1% L61 (w/w) were long-circulating, and preferentially accumulated in the tumor site. The paclitaxel-loaded L61-liposomes with a single injection dose could successfully arrest the tumor growth, lasting for five days, and displayed better treatment outcomes compared to the non-modified liposomes and even the PEGylated liposomes.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
Recommended Compounds
2-Methyl-2-propanyl (2R)-2-formyl-1-piperidinecarboxylate
CAS Number:
134526-69-5
Molecular Formula:
C11H19NO3
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