Experimental and theoretical study of the metastable decay of negatively charged nucleosides in the gas phase

Literature Information

Publication Date 2011-07-18
DOI 10.1039/C1CP21298B
Impact Factor 3.676
Authors

Helga Dögg Flosadóttir, Hannes Jónsson, Snorri Th. Sigurdsson, Oddur Ingólfsson


View Original

Abstract

Fragmentation of metastable anions of all deoxynucleosides and nucleosides constituting DNA and RNA has been studied experimentally and by computer simulations. The ions were formed through deprotonation in matrix assisted laser desorption/ionisation (MALDI). Clear difference in fragmentation patterns was obtained for nucleosides containing purinevs.pyrimidine bases. To elucidate the role of various potential deprotonation sites, systematic blocking by chemical modification was performed and this gave unambiguous correlation between deprotonation sites and fragments observed. Classical dynamics simulations of the fragmentation process, using density functional theory to describe the electronic degrees of freedom, were performed for the various deprotonation sites. These were found to reproduce the observed fragmentation patterns remarkably well.

Related Literature

Charge transfer in steam purified arc discharge single walled carbon nanotubes filled with lutetium halides

Ana Santidrián, Magdalena Kierkowicz, Elzbieta Pach, Denisa Darvasiová, Belén Ballesteros, Gerard Tobias, Martin Kalbáč

2020-04-23 Paper

DOI: 10.1039/D0CP01408G

Hierarchical phenomena in multicomponent liquids: simulation methods, analysis, chemistry

Michael J. Servis, Ernesto Martinez-Baez

2020-03-05 Perspective

DOI: 10.1039/D0CP00164C

Influence of the type of carrier on ferromagnetism in a Si semiconductor implanted with Cu ions

Li Wang, Denglu Hou, Chunfang Wu, Yuanping Shi, Shaohui Shi, Weikun Gao, Shunzhen Feng, Yingdi Liu, Li Li, Denghui Ji

2020-03-09 Paper

DOI: 10.1039/C9CP05608D

Front cover

Cover

DOI: 10.1039/D0CP90102D

Phase separation in pore-spanning membranes induced by differences in surface adhesion

Jeremias Sibold, Vera E. Tewaag, Thomas Vagedes, Ingo Mey

2020-04-08 Paper

DOI: 10.1039/D0CP00335B

Predicting reactive sites with quantum chemical topology: carbonyl additions in multicomponent reactions

David I. Ramírez-Palma, Cesar R. García-Jacas, Pablo Carpio-Martínez, Fernando Cortés-Guzmán

2020-03-31 Paper

DOI: 10.1039/D0CP00300J

Interaction of water with oligo(ethylene glycol) terminated monolayers: wetting versus hydration

Mustafa Sayin, Alexei Nefedov, Michael Zharnikov

2020-03-27 Paper

DOI: 10.1039/D0CP00906G

Penning spectroscopy and structure of acetylene oligomers in He nanodroplets

S. Mandal, R. Gopal, M. Shcherbinin, A. D’Elia, H. Srinivas, R. Richter, B. Bapat, S. R. Krishnan, V. Sharma

2020-04-21 Paper

DOI: 10.1039/D0CP00689K

Versatile surface-active ionic liquid: construction of microemulsions and their applications in light harvesting

Pratap Bahadur, Debes Ray, V. K. Aswal

2020-03-24 Paper

DOI: 10.1039/C9CP06842B

You might also like

155412-88-71-(3-Aminophenyl)-3-...
Compound Q&A

How should waste containing 1-(D-Ribofuranosyl)-1,4-dihydro-3-pyridinecarboxamide (CAS: 19132-12-8) be handled?

Waste containing 1-(D-Ribofuranosyl)-1,4-dihydro-3-pyridinecarboxamide (CAS: 191...

19132-12-81-(D-Ribofuranosyl)-...
Compound Q&A

What regulatory guidelines apply to 2-Methyl-2-propanyl 3-bromo-3-(hydroxymethyl)-1-azetidinecarboxylate (CAS: 2007919-81-3)?

2-Methyl-2-propanyl 3-bromo-3-(hydroxymethyl)-1-azetidinecarboxylate (CAS: 20079...

2007919-81-32-Methyl-2-propanyl ...
Compound Q&A

What is N-(4-Chloro-2-pyridinyl)acetamide (CAS: 245056-66-0)?

N-(4-Chloro-2-pyridinyl)acetamide (CAS: 245056-66-0) is a chemical compound with...

245056-66-0N-(4-Chloro-2-pyridi...
Compound Q&A

What is 5-Chloro-2-hydroxybenzoic acid (CAS: 321-14-2)?

5-Chloro-2-hydroxybenzoic acid, also known as 5-chlorosalicylic acid, is an arom...

321-14-25-Chloro-2-hydroxybe...
Compound Q&A

What precautions should be taken when handling 1,1-Dichloro-1-fluoroethane (CAS: 1717-00-6)?

When handling 1,1-Dichloro-1-fluoroethane (CAS: 1717-00-6), it is important to u...

1717-00-61,1-Dichloro-1-fluor...
Compound Q&A

What are the physical and chemical properties of Fmoc-(2S,3R)-3-phenylpyrrolidine-2-carboxylic acid (CAS: 281655-32-1)?

Fmoc-(2S,3R)-3-phenylpyrrolidine-2-carboxylic acid is a white crystalline solid ...

281655-32-1Fmoc-(2S,3R)-3-pheny...
Compound Q&A

What are the main uses of 4-Amino-5-bromo-2-pyridinecarboxylic acid (CAS: 1363381-01-4)?

4-Amino-5-bromo-2-pyridinecarboxylic acid is primarily used as a precursor in th...

1363381-01-44-Amino-5-bromo-2-py...
1007881-98-2(S)-tert-butyl 2-((2...
Compound Q&A

What precautions should be taken when handling 8-bromo-2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-one (CAS: 688363-73-7)?

When handling 8-bromo-2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-one, use prop...

688363-73-78-bromo-2,2-dimethyl...

Source Journal

Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
Self-citation Rate: 10.3%
Articles per Year: 3036

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.