A synthetic approach to kingianin A based on biosynthetic speculation
Literature Information
Publication Date
2011-08-24
DOI
10.1039/C1CC13949E
Impact Factor
6.222
Authors
Pallavi Sharma, Dougal J. Ritson, James Burnley, John E. Moses
View Original
Abstract
A synthetic approach towards the structurally complex dimer, kingianin A is reported. The strategy involved a cascade of complexity generating reactions, inspired through biosynthetic speculation. A concise protecting group free synthesis of the proposed monomeric precursor pre-kingianin A has been achieved using a tandem Stille cross-coupling reaction and electrocyclisation process. However, preliminary studies of the key dimerisation reaction have been conducted, which indicate that the process is not spontaneous, raising questions as to the origin of this complex natural product.
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Chemical Communications
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