Artificial, switchable K+-gated ion channels based on flow-through titania-nanotube arrays
Literature Information
Bin Zhu, Jingjian Li, Qingwei Chen, Rui-Guo Cao, Jianming Li, Dongsheng Xu
In the present work, we demonstrated a novel type of artificial K+-gated ion channels based on titania nanotubes loaded with Au nanoparticles and G-rich DNA composite structure. K+ promoted conformational change of G-rich DNA from flexible chain to rigid quadruplex, which provided a blocking effect for the transport of anions such as Fe(CN)64− and other molecules through the channels in TiO2 nanotubes. This fabricated permselective membrane using K+ as a trigger may set light to the field of biosensing, drug-release, ion exchange membrane and so on.
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