On-capillary derivatization using a hybrid artificial neural network-genetic algorithm approach
Literature Information
Publication Date
2009-08-03
DOI
10.1039/B909143B
Impact Factor
4.616
Authors
Toni Riveros, Grady Hanrahan, Sarah Muliadi, Jennifer Arceo, Frank A. Gomez
View Original
Abstract
The first reported hybrid artificial neural network-genetic algorithm (ANN-GA) approach for the optimization of on-capillary dipeptide derivatization is presented. More specifically, genetic optimization proved valuable in the determination of effective network structure with three defined parameter inputs: (i) phthalic anhydride injection volume, (ii) time of injection, and (iii) voltage, for the maximum conversion of the dipeptideD-Ala-D-Ala by phthalic anhydride. Results obtained from the hybrid approach proved superior to an ANN model without GA optimization in terms of training data and predictive ability. The model developed will likely prove useful for the analysis of other organic-based reaction systems.
Recommended Journals
Molecular Diversity
Journal of Enzyme inhibition and Medicinal Chemistry
Physical Chemistry Chemical Physics
European Journal of Organic Chemistry
Contact Lens & Anterior Eye
Photochemical & Photobiological Sciences
Nature Reviews Drug Discovery
Angewandte Chemie International Edition
Current Pharmaceutical Biotechnology
Foundations of Chemistry
Related Literature
Solvent effects in the photodenitrogenation of the azoalkane diazabicyclo[2.2.1]hept-2-ene: viscosity- and polarity-controlled stereoselectivity in housane formation from the diazenyl diradical
Waldemar Adam, Manfred Diedering
2002-02-13
Paper
DOI: 10.1039/B110562K
On the response of simple reactors to regular trains of pulses
2002-03-12
Paper
DOI: 10.1039/B109522F
Dipole strength effects on the polymorphism in smectic A mesophases
2002-01-23
Paper
DOI: 10.1039/B106788E
P–ρ–T and Ps–ρs–Ts properties of methanol + water and n-propanol + water solutions in wide range of state parameters
2002-02-18
Paper
DOI: 10.1039/B109077C
From degeneration to damping of electrochemical oscillation induced by temperature controlling of heat-compensation type
Jinglei Lei, Jiuli Luo
2002-02-19
Paper
DOI: 10.1039/B108572G
Nanostructuring of a sodium dodecyl sulfate-covered Au(111) electrode
Marc Petri, Dieter M. Kolb
2002-02-22
Paper
DOI: 10.1039/B110142K
Use of ab initio interaction energies for the prediction of phase equilibria in the system nitrogen–ethane
Gabriele Raabe, Juergen Koehler
2002-01-14
Paper
DOI: 10.1039/B108641N
Femtosecond velocity map imaging of dissociative ionization dynamics in CF3I
Wim G. Roeterdink, Maurice H. M. Janssen
2002-01-16
Paper
DOI: 10.1039/B107897F
Density function studies of peptides Part I. Vibrational frequencies including isotopic effects and NMR chemical shifts of N-methylacetamide, a peptide model, from density function and MP2 calculations
G. Cuevas, G. Madrid, A. T. Hagler
2002-03-15
Paper
DOI: 10.1039/B110777C
You might also like
Compound Q&A
What regulatory guidelines apply to 6-Bromo-2-methylimidazo[1,2-a]pyrimidine (CAS: 1111638-05-1)?
6-Bromo-2-methylimidazo[1,2-a]pyrimidine (CAS: 1111638-05-1) falls under various...
1111638-05-16-Bromo-2-methylimid...
Compound Q&A
Are there alternatives to 1-Pyrrolidineethanol, β-methyl-α-phenyl-, (αS,βR) (CAS: 123620-80-4) in synthesis?
While there are no direct alternatives, similar compounds like 1-Pyrrolidineetha...
123620-80-41-Pyrrolidineethanol...
Compound Q&A
Is 4-Methyl-2,6-bis(2-methyl-2-propanyl)phenyl methylcarbamate (CAS: 1918-11-2) safe?
4-Methyl-2,6-bis(2-methyl-2-propanyl)phenyl methylcarbamate (CAS: 1918-11-2) is ...
1918-11-24-Methyl-2,6-bis(2-m...
Compound Q&A
How should 2-(3-Bromo-4-fluorophenyl)-1,3-dioxolane (CAS: 77771-04-1) be stored?
2-(3-Bromo-4-fluorophenyl)-1,3-dioxolane (CAS: 77771-04-1) should be stored in a...
77771-04-12-(3-Bromo-4-fluorop...
Compound Q&A
What are the physical and chemical properties of 4,5,6,7-Tetrahydro-1H-indazole hydrochloride (CAS: 18161-11-0)?
4,5,6,7-Tetrahydro-1H-indazole hydrochloride is a white crystalline solid with a...
18161-11-04,5,6,7-Tetrahydro-1...
Compound Q&A
What is (2R)-1-Methoxy-3-phenyl-2-propanamine (CAS: 59919-07-2)?
(2R)-1-Methoxy-3-phenyl-2-propanamine is a chiral organic compound with the CAS ...
59919-07-2(2R)-1-Methoxy-3-phe...
Compound Q&A
What industries use Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate (CAS: 56649-47-9)?
Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate is used in various industries...
56649-47-9Ethyl 1-(1-phenyleth...
Compound Q&A
What regulatory guidelines apply to 4-[(1E,3S)-1-(4-Hydroxyphenyl)-1,4-pentadien-3-yl]phenol (CAS: 17676-24-3)?
4-[(1E,3S)-1-(4-Hydroxyphenyl)-1,4-pentadien-3-yl]phenol (CAS: 17676-24-3) falls...
17676-24-34-[(1E,3S)-1-(4-Hydr...
Compound Q&A
What industries use (S)-3-Amino-5-phenylpentanoic acid hydrochloride (CAS: 331846-97-0)?
(S)-3-Amino-5-phenylpentanoic acid hydrochloride is primarily used in the pharma...
331846-97-0(S)-3-Amino-5-phenyl...
Compound Q&A
How is 7-methoxy-1-benzothiophene-2-carboxylic acid (CAS: 88791-07-5) typically synthesized?
7-Methoxy-1-benzothiophene-2-carboxylic acid is typically synthesized by reactin...
88791-07-57-methoxy-1-benzothi...
Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
653
Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.