2,3-Functionalization of furans, benzofurans and thiophenesvia magnesiation and sulfoxide–magnesium exchange

Literature Information

Publication Date 2009-05-20
DOI 10.1039/B907330B
Impact Factor 6.222
Authors

Laurin Melzig, Christian B. Rauhut, Paul Knochel


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Abstract

The use of TMPMgCl·LiCl and iPrMgCl·LiCl allows a sequential 2,3-difunctionalization of various 2-arylsulfinyl furans, thiophenes and benzofurans. Subsequent use of the same reagents permits a selective full functionalization of all 4 positions of the furan and thiophene scaffolds.

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