99m-Technetium carbohydrate conjugates as potential agents in molecular imaging

Literature Information

Publication Date 2008-09-12
DOI 10.1039/B809365B
Impact Factor 6.222
Authors

Meryn L. Bowen, Chris Orvig


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Abstract

This feature article covers recent reports of work towards the development of 99mTc–carbohydrate based agents for use in SPECT imaging, particularly of cancerous tissue. An outline of some of the key biological functions and coordination chemistry of carbohydrates is given, along with an introduction to bioconjugation and molecular imaging. Technetium coordination chemistry and the subset of this involving bioconjugates are discussed before moving into the focus of the article: glycoconjugates of 99mTc(V) and the more recently developed [99mTc(I)(CO)3]+. Significant work in the last decade has featured the very attractive [99mTc(CO)3]+ core, and the ligand sets designed for this core are discussed in detail.

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