G-quadruplex recognition by bis-indole carboxamides

Literature Information

Publication Date 2008-06-05
DOI 10.1039/B806042H
Impact Factor 6.222
Authors

Jyotirmayee Dash, Pravin S. Shirude, Shankar Balasubramanian


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Abstract

Herein we report the de novo design and synthesis of a geometrically flexible bis-indole carboxamide and a constrained derivative, as a novel class of small molecule scaffold that exhibits high stabilization potential for DNA G-quadruplex sequences associated with the promoters of c-kit2 and c-myc.

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