Mechanistic investigation of the gold-catalyzed aerobic oxidation of aldehydes: added insight from Hammett studies and isotopic labelling experiments
Literature Information
Peter Fristrup, Louise Bahn Johansen, Claus Hviid Christensen
The gold-catalyzed aerobic oxidation of aldehydes proceeds through development of a partial negative charge and has a significant kinetic isotope effect (kH/kD = 2.8–2.9), which illustrates that activation of the C–H bond takes place in the rate-determining step.
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