Mechanistic investigation of the gold-catalyzed aerobic oxidation of aldehydes: added insight from Hammett studies and isotopic labelling experiments

Literature Information

Publication Date 2008-03-31
DOI 10.1039/B803270J
Impact Factor 6.222
Authors

Peter Fristrup, Louise Bahn Johansen, Claus Hviid Christensen


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Abstract

The gold-catalyzed aerobic oxidation of aldehydes proceeds through development of a partial negative charge and has a significant kinetic isotope effect (kH/kD = 2.8–2.9), which illustrates that activation of the C–H bond takes place in the rate-determining step.

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DOI: 10.1039/C6QO90027E

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