Copper-mediated oxidative difluoromethylation of terminal alkynes with TMSCF2H
Literature Information
Publication Date
2015-06-29
DOI
10.1039/C5QO00186B
Impact Factor
5.281
Authors
Sheng-Qing Zhu, Xiu-Hua Xu
View Original
Abstract
A copper-mediated oxidative difluoromethylation of terminal alkynes using nucleophilic TMSCF2H in the presence of an oxidant 9,10-phenanthraquinone was developed. This reaction provided a direct and efficient method for preparation of difluoromethylated alkynes.
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Organic Chemistry Frontiers
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Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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