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Aza-Knoevenagel-type condensation of secondary amides: direct access to N-monosubstituted β,β-difunctionalized enamines‡
Literature Information
Publication Date
2015-07-20
DOI
10.1039/C5QO00191A
Impact Factor
5.281
Authors
Wei Ou, Jian-Liang Ye
View Original
Abstract
An efficient approach to N-monosubstituted β,β-difunctionalized enamines, a class of versatile building blocks for the synthesis of bioactive compounds, is reported. The method is based on the triflic anhydride-mediated direct aza-Knoevenagel-type condensation of secondary amides with active methylene compounds. The reaction showed good chemoselectivity and functional group tolerance. A number of title compounds have been synthesized in good to excellent yields in one pot from readily available starting materials.
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Source Journal
Organic Chemistry Frontiers
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