Efficient base catalyzed alkylation reactions with aziridine electrophiles
Literature Information
Thomas A. Moss, Aurelie Alba, David Hepworth, Darren J. Dixon
N-Mesitylene sulfonyl and N-tosyl aziridines have been identified as effective electrophiles in alkylation reactions of carbon acids catalyzed by the organic phosphorine base BEMP; yields of up to 99% for a range of pro-nucleophiles under mild reaction conditions are reported.
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