Efficient base catalyzed alkylation reactions with aziridine electrophiles

Literature Information

Publication Date 2008-03-27
DOI 10.1039/B802447B
Impact Factor 6.222
Authors

Thomas A. Moss, Aurelie Alba, David Hepworth, Darren J. Dixon


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Abstract

N-Mesitylene sulfonyl and N-tosyl aziridines have been identified as effective electrophiles in alkylation reactions of carbon acids catalyzed by the organic phosphorine base BEMP; yields of up to 99% for a range of pro-nucleophiles under mild reaction conditions are reported.

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