Chiral tertiary 2-furyl alcohols: diversified key intermediates to bioactive compounds. Their enantioselective synthesis via (2-furyl)aluminium addition to ketones catalyzed by a titanium catalyst of (S)-BINOL
Literature Information
Kuo-Hui Wu, Da-Wei Chuang, Chien-An Chen, Han-Mou Gau
Novel asymmetric 2-furyl additions of (2-furyl)AlEt2(THF) to aromatic ketones and one α,β-unsaturated ketone catalyzed by a titanium catalyst of 10–20 mol% (S)-BINOL are reported to furnish tertiary furyl alcohols in good to excellent enantioselectivities of 87–93% ee.
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