Single molecule conformational analysis of the biologically relevant DNA G-quadruplex in the promoter of the proto-oncogene c-MYC

Literature Information

Publication Date 2008-03-20
DOI 10.1039/B801465E
Impact Factor 6.222
Authors

Pravin S. Shirude, Liming Ying, Shankar Balasubramanian


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Abstract

Single molecule fluorescence spectroscopy has been employed to resolve the conformational heterogeneity, hybridization kinetics and study mutational effects on the c-MYC promoter G-quadruplex.

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