Structural features of the Cu(ii) complex with the rat Aβ(1–28) fragment

Literature Information

Publication Date 2007-10-29
DOI 10.1039/B713453C
Impact Factor 6.222
Authors

Elena Gaggelli, Zbigniew Grzonka, Henryk Kozłowski, Caterina Migliorini, Elena Molteni, Daniela Valensin, Gianni Valensin


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Abstract

The interaction between Cu(II) and the rat amyloid β (1–28) fragment in micellar solutions at pH 7.5 was investigated by CD and NMR spectroscopy; the proton–copper distances were used in restrained molecular dynamics simulations to obtain a structural model of the Cu(II) complex.

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