Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens

Literature Information

Publication Date 2007-02-22
DOI 10.1039/B700613F
Impact Factor 6.222
Authors

Ji'en Wu, Sian M. Cooper, Russell J. Cox, John Crosby, Matthew P. Crump, Joanne Hothersall, Thomas J. Simpson, Christopher M. Thomas, Christine L. Willis


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Abstract

Mutation of the HMG-CoA synthase encoding mupH gene in Pseudomonas fluorescens gives rise to a new metabolite formed from a truncated polyketide intermediate, providing in vivo evidence for the roles of mupH and cognate genes found in several “AT-less” and other bacterial PKS gene clusters responsible for the biosynthesis of diverse metabolites containing acetate/propionate derived side chains.

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