First hypervalent iodine(iii)-catalyzed C–N bond forming reaction: catalytic spirocyclization of amides to N-fused spirolactams

Literature Information

Publication Date 2006-12-22
DOI 10.1039/B616510A
Impact Factor 6.222
Authors

Toshifumi Dohi, Akinobu Maruyama, Yutaka Minamitsuji, Naoko Takenaga, Yasuyuki Kita


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Abstract

A protic solvent, 2,2,2-trifluoroethanol (CF3CH2OH), was successfully introduced into hypervalent iodine(III)-involved catalytic cycles as an effective solvent, and the first iodoarene-catalyzed intramolecular carbon–nitrogen bond forming reaction was achieved under strong acid-free and mild conditions.

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