α-Amino acid Tröger base derivatives, possible conformationally restricted scaffolds?‡

Literature Information

Publication Date 2006-12-15
DOI 10.1039/B614371G
Impact Factor 6.222
Authors

Sean P. Bew, Laurent Legentil, Vincent Scholier, Sunil V. Sharma


View Original

Abstract

The first synthesis of innovative α-amino acid conjugates of Tröger base is reported; their potential application as conformationally restricted scaffolds is proposed and has been investigated using high level ab initio calculations.

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