Rhodium-catalyzed tandem cyclization–cycloaddition reactions of enynebenzaldehydes: construction of polycyclic ring systems

Literature Information

Publication Date 2005-07-29
DOI 10.1039/B506003F
Impact Factor 6.222
Authors

Seunghoon Shin, Arun Kumar Gupta, Chul Yun Rhim, Chang Ho Oh


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Abstract

o-(1,6-Enynyl)benzaldehydes underwent a novel mode of cycloaddition using Rh(I)-precatalyst, via [3 + 2] cycloaddition of presumed dipolar carbonyl ylide intermediate generated by Rh-catalyst and the utility of this mechanistically intriguing enyne cyclization can be found in a number of polycyclic natural product skeletons.

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