Assessing a sustainable manufacturing route to lapatinib
Literature Information
Publication Date
2022-08-09
DOI
10.1039/D2RE00267A
Impact Factor
4.239
Authors
Roderick T. Stark, Dominic R. Pye, Wenyi Chen, Oliver J. Newton, Benjamin J. Deadman, Philip W. Miller, Jenny-Lee Panayides, Darren L. Riley, Klaus Hellgardt
View Original
Abstract
A synthetic route to an anti-cancer drug, lapatinib, was devised to support the development of a sustainable manufacturing process in South Africa. Quantitative metrics were employed to evaluate the sustainability of the key steps of the reaction.
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Source Journal
Reaction Chemistry & Engineering
CiteScore:
0
Self-citation Rate:
8.8%
Articles per Year:
284
Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.
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