Enforcing solution phase nanoscopic aggregation in a palindromic tripeptide

Literature Information

Publication Date 2005-02-28
DOI 10.1039/B500654F
Impact Factor 6.222
Authors

K. Krishna Prasad, C. S. Purohit, Alok Jain, R. Sankararamakrishnan, Sandeep Verma


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Abstract

C-terminal dimerization of a tripeptide palindrome afforded fibrillation in solution through an assembly probably driven by hydrogen bonding and hydrophobic contributions; such an approach provides an expeditious entry into fabrication of fibrillating peptides from non-fibrillating peptide sequences.

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