Dielectric investigation of the temperature dependence of the dynamics of a hydrated protein

Literature Information

Publication Date 2004-02-18
DOI 10.1039/B314046F
Impact Factor 3.676
Authors

F. Bruni, S. E. Pagnotta


View Original

Abstract

We have investigated the dielectric properties, as a function of frequency and temperature, of the hydrated globular protein lysozyme. A large data set made up by measurements performed with a conventional capacitance bridge and with a dielectric broadband apparatus on the same sample has allowed us to identify two dielectric dispersions. The main dispersion is due to migrating protons along hydrogen bonded water molecules adsorbed on the protein surface. The dynamics of these charges has many analogies with that of proton glasses and other glass forming materials. Remarkably, the proton glass transition temperature, Tg, coincides with the temperature indicating the onset of hydrogen bond network dynamics at the protein–water interface. On the other hand, the second dispersion does not show any glassy behavior; this is attributed to small scale motions of protein side chains triggered by solvent, thus providing compelling evidence of the interplay between hydration water and protein dynamics, with possible implication for catalytic activity.

Related Literature

Azlactone-based heterobifunctional linkers with orthogonal clickable groups: efficient tools for bioconjugation with complete atom economy

Hien The Ho, Alexandre Bénard, Gwenaël Forcher, Maël Le Bohec, Véronique Montembault, Sagrario Pascual, Laurent Fontaine

2018-09-19 Communication

DOI: 10.1039/C8OB01807C

Catalytic asymmetric Henry reactions of silyl nitronates with aldehydes

Tine Risgaard, Kurt V. Gothelf, Karl Anker Jørgensen

2002-12-03 Paper

DOI: 10.1039/B208859M

Synthesis of nitrogen-tethered 1,6-enynes through CuI/TFA catalysis

Leilei Cao, Liliang Huang, Xianjun Xu

2021-12-03 Research Article

DOI: 10.1039/D1QO01358K

Chemoselective synthesis of isolated and fused fluorenones and their photophysical and antiviral properties

Ismail Althagafi, Ranjay Shaw, Rahul Panwar, Shally, Chanda Sinha, Amit Kumar, Yong-Tang Zheng, Ramendra Pratap

2018-09-19 Paper

DOI: 10.1039/C8OB01733F

A rapid cell-permeating turn-on probe for sensitive and selective detection of sulfite in living cells

Jing Xu, Da-Jun Zheng, Mi-Mi Su, Yan-Chi Chen, Qing-Cai Jiao

2018-08-30 Paper

DOI: 10.1039/C8OB01908H

A pendant peptide endows a sunscreen with water-resistance

Aubrey J. Ellison

2018-09-10 Communication

DOI: 10.1039/C8OB01773E

Inside front cover

2022-02-01 Cover

DOI: 10.1039/D2QO90009B

Preparation of polysubstituted dihydrofurans through a PhI(OAc)2-promoted haloenolcyclization of olefinic dicarbonyl compounds

Ji Liu, Qing-Yun Liu, Xing-Xiao Fang, Gong-Qing Liu, Yong Ling

2018-09-24 Paper

DOI: 10.1039/C8OB02161A

Synthesis of functionalized 2,5-dihydropyrrole derivatives via a convenient [3 + 2] annulation of azomethine ylides with allenoates

Zhusheng Huang, Zonghao Dai, Jin Zhu, Fulai Yang, Qingfa Zhou

2018-08-28 Communication

DOI: 10.1039/C8OB01946K

You might also like

Compound Q&A

Is 6-(3-Fluorophenyl)picolinic acid (CAS: 887982-40-3) safe?

6-(3-Fluorophenyl)picolinic acid is generally considered safe for laboratory use...

887982-40-36-(3-Fluorophenyl)pi...
Compound Q&A

What industries use (3R)-3-Pyrrolidinol (CAS: 2799-21-5)?

(3R)-3-Pyrrolidinol is used in the pharmaceutical industry as a precursor for dr...

2799-21-5(3R)-3-Pyrrolidinol
Compound Q&A

What precautions should be taken when handling (4R,5R)-4,5-Diethoxycarbonyl-2,2-dimethyldioxolane (CAS: 59779-75-8)?

When handling (4R,5R)-4,5-Diethoxycarbonyl-2,2-dimethyldioxolane (CAS: 59779-75-...

59779-75-8(4R,5R)-4,5-Diethoxy...
Compound Q&A

How is 1-(6-Chloroimidazo[1,2-b]pyridazin-3-yl)ethanone (CAS: 90734-71-7) typically synthesized?

1-(6-Chloroimidazo[1,2-b]pyridazin-3-yl)ethanone is often synthesized via a mult...

90734-71-71-(6-Chloroimidazo[1...
Compound Q&A

What is the market or research trend for N-Ethyl-3,4-dimethylbenzylamine (CAS: 39180-83-1)?

The market for N-Ethyl-3,4-dimethylbenzylamine (CAS: 39180-83-1) remains steady,...

39180-83-1N-Ethyl-3,4-dimethyl...
Compound Q&A

What is Tert-butyl 3-(pyrrolidin-1-yl)azetidine-1-carboxylate (CAS: 1019008-21-9)?

Tert-butyl 3-(pyrrolidin-1-yl)azetidine-1-carboxylate is a chemical compound wit...

1019008-21-9Tert-butyl 3-(pyrrol...
Compound Q&A

What regulatory guidelines apply to 1-Bromo-3-chloro-2,4-dimethoxybenzene (CAS: 1228956-93-1)?

1-Bromo-3-chloro-2,4-dimethoxybenzene (CAS: 1228956-93-1) falls under the classi...

1228956-93-11-Bromo-3-chloro-2,4...
Compound Q&A

Is 8-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one (CAS: 1368622-07-4) safe?

The safety of 8-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one (CAS: 1368622-07...

1368622-07-48-Bromo-2-methyl-3,4...
Compound Q&A

Is Benzyl [(3S)-2,6-dioxo-3-piperidinyl]carbamate (CAS: 22785-43-9) safe?

Benzyl [(3S)-2,6-dioxo-3-piperidinyl]carbamate is generally safe when handled wi...

22785-43-9Benzyl [(3S)-2,6-dio...
Compound Q&A

How should 1-{[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]sulfonyl}pyrrolidine (CAS: 928657-21-0) be stored?

1-{[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]sulfonyl}pyrrolidine s...

928657-21-01-{[4-(4,4,5,5-Tetra...

Source Journal

Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
Self-citation Rate: 10.3%
Articles per Year: 3036

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.