Synthesis of functionalized 2,5-dihydropyrrole derivatives via a convenient [3 + 2] annulation of azomethine ylides with allenoates
Literature Information
Zhusheng Huang, Zonghao Dai, Jin Zhu, Fulai Yang, Qingfa Zhou
A convenient [3 + 2] annulation of azomethine ylides with allenoates promoted by triethylamine produced highly functionalized 2,5-dihydropyrrole derivatives in moderate to excellent yields under mild conditions. The potential utility of this reaction indicates that this reaction could be performed on the gram scale and the synthesized functionalized 2,5-dihydropyrrole derivatives could be further transformed into other interesting heterocycles. The mechanism for the transformation is a tandem β-addition/Mannich cyclization process.
Related Literature
High-level QM/MM modelling predicts an arginine as the acid in the condensation reaction catalysed by citrate synthase
Marc W. van der Kamp, Adrian J. Mulholland
DOI: 10.1039/B800496J
Construction of aryl-substituted triquinanes through the interrupted Nazarov reaction
Curtis J. Rieder, Ryan J. Fradette, F. G. West
DOI: 10.1039/B800800K
A DNAzyme cascade for the amplified detection of Pb2+ ions or l-histidine
Johann Elbaz, Bella Shlyahovsky, Itamar Willner
DOI: 10.1039/B716774A
Isolation and X-ray structural characterization of tetraisopropylpyrene cation radical
Moloy Banerjee, Vijay S. Vyas, Sergey V. Lindeman, Rajendra Rathore
DOI: 10.1039/B800168E
Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex
Johanna Niesel, Antonio Pinto, Harmel W. Peindy N'Dongo, Klaus Merz, Ingo Ott, Ronald Gust, Ulrich Schatzschneider
DOI: 10.1039/B719075A
Synthesis and properties of trifluoroethoxy-coated binuclear phthalocyanine
Hideyuki Yoshiyama, Norio Shibata, Takefumi Sato, Shuichi Nakamura, Takeshi Toru
DOI: 10.1039/B800918J
Exploring the relationship between cocrystal stability and symmetry: is Wallach's rule applicable to multi-component solids?
Tomislav Friščić, László Fábián, Jonathan C. Burley, David G. Reid, Melinda J. Duer, William Jones
DOI: 10.1039/B717532A
Self-assembly of a peptide rod–coil: a polyproline rod and a cell-penetrating peptide Tat coil
You-Rim Yoon, Yong-beom Lim, Eunji Lee, Myongsoo Lee
DOI: 10.1039/B719868J
Rational design of supramolecular chirality in porphyrin assemblies: the halogen bond case‡
Sankar Muniappan, Sophia Lipstman, Israel Goldberg
DOI: 10.1039/B719625C
Highly luminescent mono- and multilayers of immobilized CdTe nanocrystals: controlling optical properties through post chemical surface modification
Takaaki Tsuruoka, Rena Takahashi, Toshihiro Nakamura, Minoru Fujii, Kensuke Akamatsu, Hidemi Nawafune
DOI: 10.1039/B717732A
You might also like
What is the market or research trend for N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0)?
N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0) is increasingly being used ...
What precautions should be taken when handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate (CAS: 1050507-06-6)?
When handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate, appropriate p...
What regulatory guidelines apply to diethyldiselane (CAS: 628-39-7)?
Diethyldiselane (CAS: 628-39-7) is classified under the Globally Harmonized Syst...
What is the market or research trend for oxocopper (CAS: 12053-18-8)?
The market for oxocopper (CAS: 12053-18-8) is primarily driven by its use in cat...
What is the market or research trend for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-carboxylic acid?
The market for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-c...
What is 2-(1-Pyrrolidinyl)-4-pyridinamine (CAS: 35981-63-6)?
2-(1-Pyrrolidinyl)-4-pyridinamine is a chemical compound with the CAS number 359...
What are the physical and chemical properties of 2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1)?
2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1) is a crystalline sol...
How is (S)-Alpha-allyl-proline hydrochloride (CAS: 129704-91-2) typically synthesized?
(S)-Alpha-allyl-proline hydrochloride is usually synthesized via a Wittig reacti...
What is 3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5)?
3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5) is an organic compound w...
How is Lys-SMCC-DM1 (CAS: 1281816-04-3) typically synthesized?
Lys-SMCC-DM1 is synthesized via a multi-step process involving the coupling of S...
Source Journal
Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.














![1-{3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl}-2,3-dihydroxy-1-propanone structure 1-{3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl}-2,3-dihydroxy-1-propanone structure](https://static.chemtradehub.com/structs/122/1226872-27-0-e037.webp)