Synthesis of a novel C2-aryl substituted 1,2-unsaturated pyrrolobenzodiazepine

Literature Information

Publication Date 2003-06-11
DOI 10.1039/B303274D
Impact Factor 6.222
Authors

Gyoung-Dong Kang, Philip W. Howard, David E. Thurston


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Abstract

A novel C2-aryl 1,2-unsaturated PBD (14) has been prepared via an enol triflate intermediate (8). The regiochemistry of triflation is dependent upon the point at which the reaction is performed during the synthetic route.

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