Synthesis of a novel C2-aryl substituted 1,2-unsaturated pyrrolobenzodiazepine
Literature Information
Gyoung-Dong Kang, Philip W. Howard, David E. Thurston
A novel C2-aryl 1,2-unsaturated PBD (14) has been prepared via an enol triflate intermediate (8). The regiochemistry of triflation is dependent upon the point at which the reaction is performed during the synthetic route.
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