The partial molar volumes of some tetra- and pentapeptides in aqueous solution: a test of amino acid side-chain group additivity for unfolded proteins

Literature Information

Publication Date 2000-07-06
DOI 10.1039/B003034L
Impact Factor 3.676
Authors

Marko Häckel, Hans-Jürgen Hinz, Gavin R. Hedwig


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Abstract

Ten new peptides with the amino acid sequences glycyl-X-Y-glycine and glycyl-X-Y-Z-glycine, where X, Y and Z are amino acids with neutral side-chains, have been synthesized and the partial molar volumes at infinite dilution, V2°, have been determined for all these peptides in aqueous solution at 298.15 K. For several of the peptides, V2° data have also been obtained over the temperature range 283.15 to 363.15 K using a scanning densimetric method. The V2° results obtained are compared with those calculated using the principle of group additivity and the group partial molar volumes we have derived in earlier work. We have shown that our group partial molar volumes can be used to reliably predict the partial molar volumes over a wide temperature range of polypeptides that have neutral amino acid side-chains.

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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
Self-citation Rate: 10.3%
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Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

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