Asymmetric protonation of lithium enolates of α-amino acid derivatives with α-amino acid-based chiral Brønsted acids

Literature Information

Publication Date 2003-01-30
DOI 10.1039/B211523A
Impact Factor 6.222
Authors

Kentaro Futatsugi, Akira Yanagisawa, Hisashi Yamamoto


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Abstract

The reaction of lithium enolates of α-amino acid derivatives with chiral amides, easily synthesized from L-tert-leucine, gives corresponding optically active unnatural α-amino acid derivatives with up to 87% ee.

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