Nebivolol | CAS No. 99200-09-6

Nebivolol

Basic Information

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CAS Number

99200-09-6

Molecular Formula

C22H25F2NO4

Molecular Weight

405.44 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

600.5 °C at 760 mmHg

Density

1.309

Flash Point

316.9 °C

Refractive Index

1.58

SMILES

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C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O

InChI

InChI=1S/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2

InChIKey

KOHIRBRYDXPAMZ-UHFFFAOYSA-N

LogP

2.363600000000001

Topological Polar Surface Area

70.95 Å²

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

483

Synonyms & References

English

AS-77015
SR-01000883933-1
(-)-Nebivolol; Levonebivolol; l-Nebivolol
R65,824
CHEBI:64022
BYVALSON COMPONENT OF NEBIVOLOL
L001284
1,1'-bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2,2'-iminodiethanol
2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol]
FT-0672665
R-65824
SCHEMBL19863
UNII-030Y90569U
NS00003512
Nebivolol
(+-)-Nebivolol
alpha,alpha'-(iminobismethylene)bis-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
alpha,alpha'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
EN300-7392989
9920-09-6
nebibolol
AKOS015895102
PDSP1_000244
FT-0631000
FT-0672664
Nobiten
1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol
NEBIVOLOL COMPONENT OF BYVALSON
DTXSID9040556
R 67138;d-Nebivolol;(+)-Nebivolol; (S,R,R,R)-Nebivolol
A845981

MDL Number

MFCD00865796

FAQ

What regulatory guidelines apply to Nebivolol (CAS: 99200-09-6)?

Nebivolol (CAS: 99200-09-6) is regulated under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) and is classified as a pharmaceutical. It is also subject to the European Union’s Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation. Additionally, in the United States, it falls under the jurisdiction of the Food and Drug Administration (FDA) and the Environmental Protection Agency (EPA) for safety and environmental management.

Are there alternatives to Nebivolol (CAS: 99200-09-6) in synthesis?

While Nebivolol is a unique compound, there are alternative beta-blockers that can be used in synthesis, such as metoprolol and acebutolol. These alternatives can serve as effective substitutes due to their similar pharmacological properties, although their specific synthesis routes may differ from those of Nebivolol.

What is the market or research trend for Nebivolol (CAS: 99200-09-6)?

Nebivolol has shown consistent market growth due to its advantages in treating hypertension and heart failure compared to other beta-blockers. Research trends indicate increasing interest in its cardiovascular benefits and potential as a cardioprotective agent. However, market trends are influenced by regulatory updates and clinical trial outcomes.

How should waste containing Nebivolol (CAS: 99200-09-6) be handled?

Waste containing Nebivolol should be collected in appropriate containers and disposed of according to local regulations. It is typically classified as hazardous waste due to its pharmaceutical nature. Incineration, professional waste disposal services, and adherence to environmental protection precautions are recommended to ensure safe and compliant disposal. Always consult the Material Safety Data Sheet (MSDS) for specific handling and disposal instructions.