5-(Methylsulfanyl)-1,3-thiazol-2-amine

Basic Information

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CAS Number

99171-11-6

Molecular Formula

C4H6N2S2

Molecular Weight

146.24 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

303.5°C at 760 mmHg

Density

1.37±0.1 g/cm3 (20 ºC 760 Torr),

Flash Point

137.4°C

Refractive Index

1.652

SMILES

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CSC1=CN=C(S1)N

InChI

InChI=1S/C4H6N2S2/c1-7-3-2-6-4(5)8-3/h2H,1H3,(H2,5,6)

InChIKey

KVLWIPGOGRZZEA-UHFFFAOYSA-N

LogP

1.4471999999999998

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

78.4

Synonyms & References

English

5-methylsulfanyl-1,3-thiazol-2-amine
DTXSID40326014
5-Methylsulfanylthiazol-2-ylamine
NSC522650
KVLWIPGOGRZZEA-UHFFFAOYSA-N
2-Thiazolamine, 5-(methylthio)-
99171-11-6
NSC-522650
5-(Methylthio)thiazol-2-amine
MFCD09943153
CS-0150103
5-(METHYLSULFANYL)-1,3-THIAZOL-2-AMINE
2-Thiazolamine,5-(methylthio)-
5-(methylthio)-1,3-thiazol-2-amine
SCHEMBL702948
C77378
BS-50228
AKOS000187477
2-amino-5-(methylthio)thiazole
5-(Methylthio)-2-Thiazolamine
5-Methylmercapto-thiazol-2-ylamin
5-methylsulfanyl-thiazol-2-ylamine
Thiazole,2-amino-5-(methylthio)
NSC 522650
Thiazole, 2-amino-5-(methylthio)
6948AC
FCH2582690
AK101162
AX8232701
AB1010125

MDL Number

MFCD09943153

Customs Code

2934100090

FAQ

What are the physical and chemical properties of 5-(Methylsulfanyl)-1,3-thiazol-2-amine (CAS: 99171-11-6)?

5-(Methylsulfanyl)-1,3-thiazol-2-amine is a white or off-white crystalline solid with a molecular weight of approximately 146.19 g/mol. It is slightly soluble in water and soluble in polar organic solvents like dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). This compound is reactive towards nucleophiles and can form amide bonds. It also shows moderate basicity in aqueous solutions.

How is 5-(Methylsulfanyl)-1,3-thiazol-2-amine (CAS: 99171-11-6) typically synthesized?

5-(Methylsulfanyl)-1,3-thiazol-2-amine is typically synthesized via amination of 5-(methylthio)-1,3-thiazole with methylamine. Commonly, this can be achieved using sodium methylate in a polar aprotic solvent like dimethylformamide (DMF). The reaction proceeds with good yield and selectivity, though the exact conditions may vary.

What industries use 5-(Methylsulfanyl)-1,3-thiazol-2-amine (CAS: 99171-11-6)?

5-(Methylsulfanyl)-1,3-thiazol-2-amine finds applications in the pharmaceutical industry as a precursor in the synthesis of various thiazole-containing drugs. It is also used in the polymer industry for functionalization of polymers, in sensor technology for detecting sulfur compounds, and in semiconductor technology for certain chemical vapor deposition processes.

What precautions should be taken when handling 5-(Methylsulfanyl)-1,3-thiazol-2-amine (CAS: 99171-11-6)?

When handling 5-(Methylsulfanyl)-1,3-thiazol-2-amine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to vapors. Spills should be carefully cleaned up using appropriate absorbents, and proper disposal methods should be followed. Always consult the Safety Data Sheet (SDS) for detailed information on handling and storage.