Paracetamol EP Impurity E

Basic Information

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CAS Number

99-93-4

Molecular Formula

C8H8O2

Molecular Weight

136.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Cryst.

Melting Point

109-111 °C

Boiling Point

147-148 °C/3 mmHg

Density

1.109

Water Solubility

10 g/L (22 ºC)

Flash Point

166 ºC

Solubility

methanol: 0.1 g/mL, clear

Refractive Index

1.5577 (estimate)

Vapor Pressure

0.0±0.7 mmHg at 25°C

SMILES

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CC(=O)c1ccc(O)cc1

InChI

InChI=1S/C8H8O2/c1-6(9)7-2-4-8(10)5-3-7/h2-5,10H,1H3

InChIKey

TXFPEBPIARQUIG-UHFFFAOYSA-N

LogP

1.5948

pKa

8.05(at 25℃)

Topological Polar Surface Area

37.3 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

123

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Storage Conditions

2-8℃

Synonyms & References

English

1-(4-Hydroxyphenyl)ethanone
1-(4-HYDROXY-PHENYL)-ETHANONE
4-ACETOPHENOL
4-ACETYLPHENOL
4-BENZOYLPHENOL
4-HYDROXYACETOPHENONE
4-HYDROXYBENZOPHENONE
4-HYDROXYPHENYL METHYL KETONE
(4-HYDROXY-PHENYL)-PHENYL-METHANONE
ACETYLPHENOL
HYDROXYACETOPHENONE-4
HYDROXYBENZOPHENONE-4
P-ACETOPHENOL
P-BENZOYLPHENOL
P-HYDROXYACETOPHENONE
P-HYDROXYBENZOPHENONE
POB
1-(4-hydroxyphenyl)-ethanon
4'-hydroxy-acetophenon
4'-Hydroxyacetophenone
4′-Hydroxyacetophenone
HYDROXYACETOPHENONE, P- (RG)
4-Hydroxyphenylethanone
p-Hydroxyphenyl methyl ketone
Piceol
[ "" ]
对羟基苯乙酮
4’-Hydroxyacetophenone
P-hydroxyacetophenone
p-Acetophenol
4-Acetophenol

MDL Number

MFCD00002359

Customs Code

2914509090

FAQ

What is Paracetamol EP Impurity E (CAS: 99-93-4)?

Paracetamol EP Impurity E (CAS: 99-93-4) is a specific impurity identified in the European Pharmacopoeia (EP) for paracetamol. It is a white crystalline solid with the molecular formula C8H10NO2 and exhibits similar chemical properties to paracetamol, including solubility in water and organic solvents. This compound is commonly used in analytical chemistry to assess purity and quality control in pharmaceutical manufacturing.

What are the main uses of Paracetamol EP Impurity E (CAS: 99-93-4)?

Paracetamol EP Impurity E (CAS: 99-93-4) is primarily used in pharmaceutical quality control to detect and quantify impurities in paracetamol production. It also serves as a reference standard in analytical testing, research, and method validation to ensure compliance with regulatory guidelines. Its applications include drug development, contamination analysis, and ensuring safety standards in medication manufacturing.

Is Paracetamol EP Impurity E (CAS: 99-93-4) safe?

Paracetamol EP Impurity E (CAS: 99-93-4) is generally considered safe in trace amounts, but it may pose health risks if exposed in high concentrations. Proper handling, such as wearing gloves and ensuring ventilation, is recommended to minimize contact. Safety standards emphasize adherence to regulatory limits, and it is critical to follow guidelines to avoid potential toxicity, especially during industrial or research use.

How should Paracetamol EP Impurity E (CAS: 99-93-4) be stored?

Paracetamol EP Impurity E (CAS: 99-93-4) should be stored in a cool, dry place, away from light, in a tightly sealed container. Maintain storage temperature below 25°C and humidity levels below 60% to ensure stability. Avoid exposure to moisture and air to prevent degradation, and store according to safety standards to maintain product integrity.