(2R)-2-Indolinecarboxylic acid

Basic Information

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CAS Number

98167-06-7

Molecular Formula

C9H9NO2

Molecular Weight

163.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

170-172°C

Flash Point

183.6℃

Specific Rotation

+116 ±3° (c=1, 1N HCl)

SMILES

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C1C(NC2=CC=CC=C21)C(=O)O

InChI

InChI=1S/C9H9NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-4,8,10H,5H2,(H,11,12)/t8-/m1/s1

InChIKey

QNRXNRGSOJZINA-MRVPVSSYSA-N

LogP

1.1078

Topological Polar Surface Area

49.33 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

193

Safety Information

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GHS Hazard Pictograms

H317

H361

Hazard Statement

H317 May cause an allergic skin reaction
Sensitization, Skin

H361 Suspected of damaging fertility or the unborn child
Reproductive toxicity

Sensitiveness

对湿度敏感

Synonyms & References

English

1H-Indole-2-carboxylic acid, 2,3-dihydro-, (2R)-
AC-1319
Indoline-2-carboxylic acid, (R)-
AS-31788
Oprea1_181429
(R)-2,3-Dihydro-1H-indole-2-carboxylic acid
InChI=1/C9H9NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-4,8,10H,5H2,(H,11,12)/t8-/m1/s1
(+)-2,3-Dihydroindole-2-carboxylic acid, 98%
I0589
QNRXNRGSOJZINA-MRVPVSSYSA-N
QNRXNRGSOJZINA-MRVPVSSYSA-
(R)-(+)-Indoline-2-carboxylicacid
SCHEMBL1134239
UNII-QY9RZ2W7PH
AKOS005259556
A15943
(R)-(+)-Indoline-2-carboxylic acid, >=97.0%
(R)-(+)-Indoline-2-carboxylic acid
DTXSID001346613
(R)-indoline-2-carboxylic acid;(R)-(+)-Indoline-2-carboxylic acid
MFCD00792496
EN300-264345
(2R)-indoline-2-carboxylic acid
98167-06-7
(R)-Indoline-2-carboxylic Acid
CS-0006681
(+)-2,3-Dihydroindole-2-carboxylic acid
(2R)-2,3-dihydro-1H-indole-2-carboxylic acid
QY9RZ2W7PH
(R)-(-)-Indoline-2-carboxylic acid
(R)-Indoline-2-carboxylic acid

MDL Number

MFCD00792496

FAQ

What are the physical and chemical properties of (2R)-2-Indolinecarboxylic acid (CAS: 98167-06-7)?

(2R)-2-Indolinecarboxylic acid is a crystalline solid with a molecular weight of approximately 174.23 g/mol. It has a pKa of about 3.8. The compound is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. It is reactive towards nucleophiles and can undergo carboxylation and esterification reactions.

How is (2R)-2-Indolinecarboxylic acid (CAS: 98167-06-7) typically synthesized?

(2R)-2-Indolinecarboxylic acid is often synthesized via the condensation of indoline-2-carboxaldehyde with itself using a suitable reducing agent like sodium borohydride. The reaction is typically carried out in an aqueous medium. Alternative methods involve the reaction of indoline-2-carboxaldehyde with a suitable amine followed by acidification.

What industries use (2R)-2-Indolinecarboxylic acid (CAS: 98167-06-7)?

(2R)-2-Indolinecarboxylic acid finds applications in the pharmaceutical industry for the synthesis of certain drugs. It is also used in the production of polymers and as a precursor in the development of new materials. Additionally, it is utilized in the field of analytical chemistry for the development of sensors and in semiconductor manufacturing.

What precautions should be taken when handling (2R)-2-Indolinecarboxylic acid (CAS: 98167-06-7)?

When handling (2R)-2-Indolinecarboxylic acid, appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat should be worn. It should be stored in a closed container at room temperature away from heat. In case of skin contact, wash with soap and water. If inhaled, move to fresh air and seek medical attention. For spills, sweep up and dispose of according to safety data sheet (SDS) guidelines.