(2R)-2-Indolinecarboxylic acid(CAS: 98167-06-7)

(2R)-2-Indolinecarboxylic acid is a crystalline solid with a molecular weight of approximately 174.23 g/mol. It has a pKa of about 3.8. The compound is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. It is reactive towards nucleophiles and can undergo carboxylation and esterification reactions.

(2R)-2-Indolinecarboxylic acid is often synthesized via the condensation of indoline-2-carboxaldehyde with itself using a suitable reducing agent like sodium borohydride. The reaction is typically carried out in an aqueous medium. Alternative methods involve the reaction of indoline-2-carboxaldehyde with a suitable amine followed by acidification.

(2R)-2-Indolinecarboxylic acid finds applications in the pharmaceutical industry for the synthesis of certain drugs. It is also used in the production of polymers and as a precursor in the development of new materials. Additionally, it is utilized in the field of analytical chemistry for the development of sensors and in semiconductor manufacturing.

When handling (2R)-2-Indolinecarboxylic acid, appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat should be worn. It should be stored in a closed container at room temperature away from heat. In case of skin contact, wash with soap and water. If inhaled, move to fresh air and seek medical attention. For spills, sweep up and dispose of according to safety data sheet (SDS) guidelines.