Niacinamide | CAS No. 98-92-0

Niacinamide

Basic Information

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CAS Number

98-92-0

Molecular Formula

C6H6N2O

Molecular Weight

122.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Powder

Melting Point

128-131 °C

Boiling Point

150-160 ºC

Density

1.400

Water Solubility

1000 g/L (20 ºC)

Solubility

691g/l

Refractive Index

1.4660 (estimate)

Vapor Pressure

4.2X10-4 mm Hg at 25 °C (est)

Vapor Density

Relative vapor density (air = 1): 4.2

Odor

Odorless

SMILES

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C1=CC(=CN=C1)C(=O)N

InChI

InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChIKey

DFPAKSUCGFBDDF-UHFFFAOYSA-N

LogP

0.18050000000000016

pKa

3.3(at 20℃)

Topological Polar Surface Area

55.980000000000004 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

114

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Storage Conditions

N/A

Stability

Stable. Incompatible with strong oxidizing agents.

Sensitiveness

responsive to light

Toxicity

LD50 s.c. in rats: 1.68 g/kg (Brazda, Coulson)

Synonyms & References

English

Nicotinamide
VB3
VPP
Pyridine-3-carboxamide
niacinamide cell culture tested
Nicotinamide (1.06818)
Niacinamide
Vitamin PP
Pyridine-3-Carboxyamide
3-Pyridinecarboxamide
Nicotinamide (Niacinamide)
Nicotinamide (Vitamin B3)
Nicotinamide (Vitamin B3) solution
VITAMIN B3(NIACINAMIDE)(P) PrintBack
VITAMIN B3(NIACINAMIDE)(SH)
Nicotinamide INCI
3-Pyridinecarboxylic acid aMide
Nicotinic acid amide
Vitamin B3
3-Pyridinecarboxamide
Papulex
Nicobion
Amixicotyn
Aminicotin
Nicotylamide
Savacotyl
Nikotinamid
Pelmine
Dipegyl
Benicot
Hansamid

MDL Number

MFCD00006395

Customs Code

29362990

FAQ

What is Niacinamide (CAS: 98-92-0)?

Niacinamide, with CAS number 98-92-0, is a form of vitamin B3 (niacin) used in skincare, supplements, and industry. It has the chemical formula C6H5NO2 and is a white crystalline powder. Niacinamide is water-soluble, stable in neutral pH, and resistant to heat. It acts as a precursor for nicotinamide adenine dinucleotide (NAD), playing key roles in metabolic processes. Its versatility makes it a valuable compound in various scientific and commercial applications.

What are the main uses of Niacinamide (CAS: 98-92-0)?

Niacinamide (CAS: 98-92-0) is widely used in skincare for its anti-aging and acne-reducing properties. In pharmaceuticals, it treats conditions like pellagra and supports skin health. It serves as a food additive to enhance nutrient content and is used in industrial processes for dye production and chemical synthesis. Researchers also study its role in DNA repair and metabolic functions, making it essential across multiple fields.

Is Niacinamide (CAS: 98-92-0) safe?

Niacinamide (CAS: 98-92-0) is generally safe with low toxicity. When ingested, it may cause mild side effects like flushing or gastrointestinal discomfort. Proper handling in labs or industrial settings requires gloves and eye protection to avoid skin or mucous membrane irritation. It adheres to safety standards set by regulatory bodies, ensuring safe use in cosmetics, food, and pharmaceuticals when following guidelines.

How should Niacinamide (CAS: 98-92-0) be stored?

Niacinamide (CAS: 98-92-0) should be stored in a cool, dry place away from light. Keep in a sealed container to prevent moisture absorption and contamination. It remains stable under normal storage conditions but may degrade if exposed to high temperatures or humidity. Avoid storing with incompatible substances and ensure it is out of reach of children for safety.