Irinotecan | CAS No. 97682-44-5

Irinotecan

Basic Information

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CAS Number

97682-44-5

Molecular Formula

C33H38N4O6

Molecular Weight

586.69 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

210-223°C

Solubility

Soluble

SMILES

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CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7

InChI

InChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3/t33-/m0/s1

InChIKey

UWKQSNNFCGGAFS-XIFFEERXSA-N

LogP

4.0911000000000035

Topological Polar Surface Area

114.19999999999999 Å²

Hydrogen Bond Donor/Acceptor

1 / 10

Complexity

1200

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Irinotecan
1,4'-bipiperidine-1'-carboxylic acid (s)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester
(+)-Irinotecan
CAMPTOSAR
Irinotecan,free base（CPT-11, Camptothecin 11,U-101440E,DQ-2805）
+-Irinotecan
7-ethoxyxanthone-3-carboxylic acid
9H-Xanthene-3-carboxylic acid,7-ethoxy-9-oxo
CPT-11
1,4'-Bipiperidine-1'-carboxylic acid (S)-4,11-diethyl-3,4,12,14- tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester
Irinotecanum
Irinotecanum [INN-Latin]
Irinotecan lactone
Campto
Irinotecan mylan
Irinophore C
Irinotecan [INN:BAN]
Onivyde
C33H38N4O6
AK163712
product-irinotecan
1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline, [1,4′-bipiperidine]-1′-carboxylic acid deriv. (ZCI)
[1,4′-Bipiperidine]-1′-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, (S)- (ZCI)
(19S)-10,19-Diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate
ZINC 1612996
CHEBI:80630
(diethyl-hydroxy-dioxo-[?]yl) 4-(1-piperidyl)piperidine-1-carboxylate
CPT-11 hydrochloride;Camptothecin 11 hydrochloride
NSC 728073
DB00762
AB00698464_12

MDL Number

MFCD00866307

FAQ

What is Irinotecan (CAS: 97682-44-5)?

Irinotecan (CAS: 97682-44-5) is a chemotherapy drug belonging to the camptothecin family. It has the chemical formula C23H24N2O5 and is a prodrug that becomes active in the body. Irinotecan works by inhibiting topoisomerase I, an enzyme essential for DNA replication, making it effective against various cancers.

What are the main uses of Irinotecan (CAS: 97682-44-5)?

Irinotecan (CAS: 97682-44-5) is primarily used in oncology to treat colorectal cancer, often as part of combination therapy. It also shows efficacy in other malignancies like breast, lung, and pancreatic cancers. As a chemotherapy agent, it is administered intravenously to target rapidly dividing cancer cells.

Is Irinotecan (CAS: 97682-44-5) safe?

Irinotecan (CAS: 97682-44-5) is a potent cytotoxic agent and requires strict safety protocols. Its use is regulated by health authorities like the FDA, and safety depends on proper handling by trained professionals. Precautions include wearing protective gear and avoiding exposure to non-occupational individuals due to potential toxicity.

How should Irinotecan (CAS: 97682-44-5) be stored?

Irinotecan (CAS: 97682-44-5) should be stored in a cool, dry place protected from light. It is typically kept at 2-8°C in tightly sealed containers. Ensure storage away from incompatible substances and follow manufacturer guidelines for stability and shelf life to maintain effectiveness.