Canrenone | CAS No. 976-71-6

Canrenone

Basic Information

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CAS Number

976-71-6

Molecular Formula

C22H28O3

Molecular Weight

340.46 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Basic Physical Properties

Physical State

Powder

Melting Point

160-167°C

Boiling Point

416.25°C (rough estimate)

Density

1.1236 (rough estimate)

Solubility

DMSO: soluble20mg/mL, clear

Refractive Index

1.5000 (estimate)

Specific Rotation

+24 ~ +30° (c=1, CHCl3)

SMILES

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CC12CCC(=O)C=C1C=CC3C2CCC4(C3CCC45CCC(=O)O5)C

InChI

InChI=1S/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1

InChIKey

UJVLDDZCTMKXJK-WNHSNXHDSA-N

LogP

4.370100000000003

Topological Polar Surface Area

43.370000000000005 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

719

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Canrenone
1 WEEK
ALDADIENE
CANRENONE-D4
phanurane
(17α)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid γ-lactone
NSC 261713
17-hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylic acid gamma-lactone
Luvion
Aldadiene (VAN)
Canrenonum [INN-Latin]
Canrenone [USAN:INN]
Canrenona [INN-Spanish]
11614 R.P
Spironolactone Related Compound A
78O20X9J0U
DSSTox_RID_81231
DSSTox_CID_25930
DSSTox_GSID_45930
Canrenonum
Canrenona
17α-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, γ-lactone (6CI, 7CI, 8CI)
Spiro[17H-cyclopenta[a]phenanthrene-17,2′(5′H)-furan], pregna-4,6-diene-21-carboxylic acid deriv. (ZCI)
11614 R.P.
17-Hydroxy-3-oxo-17α-pregna-4,6-diene-21-carboxylic acid lactone
17-Hydroxy-3-oxo-17α-pregna-4,6-diene-21-carboxylic acid γ-lactone
17α-(2-Carboxyethyl)-17β-hydroxyandrosta-4,6-dien-3-one lactone
17β-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid
20-Spiroxa-4,6-diene-3,21-dione
3-(17β-Hydroxy-3-oxoandrosta-4,6-dien-17α-yl)propionic acid lactone
3-(17β-Hydroxy-3-oxoandrosta-4,6-dien-17α-yl)propionic acid γ-lactone

MDL Number

MFCD00071735

Customs Code

29329990

FAQ

What is Canrenone (CAS: 976-71-6)?

Canrenone is a nonsteroidal aldosterone antagonist used in the treatment of hypertension and edema. Its chemical formula is C17H16O3. It is a white crystalline powder with an amphoteric nature and a melting point of 200-202°C.

What are the main uses of Canrenone (CAS: 976-71-6)?

Canrenone is primarily used in the treatment of hypertension and edema. It works by blocking the action of aldosterone, a hormone that regulates sodium and water balance in the body.

Is Canrenone (CAS: 976-71-6) safe?

Canrenone is generally considered safe when used as directed. However, it is important to follow medical guidance to avoid potential side effects such as electrolyte imbalances, hyperkalemia, and hyperuricemia. Always consult a healthcare professional before starting or stopping any medication.

How should Canrenone (CAS: 976-71-6) be stored?

Canrenone should be stored in a tightly closed container at room temperature (15-30°C) away from direct sunlight. Keep it in a dry place and avoid exposure to moisture and excessive humidity to ensure its stability and efficacy.