Troglitazone | CAS No. 97322-87-7

Troglitazone

Basic Information

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CAS Number

97322-87-7

Molecular Formula

C24H27NO5S

Molecular Weight

441.55 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

184-186°C

Boiling Point

657°C at 760 mmHg

Solubility

DMSO: 20 mg/mL

SMILES

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CC1=C(C2=C(CCC(O2)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C(=C1O)C)C

InChI

InChI=1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)

InChIKey

GXPHKUHSUJUWKP-UHFFFAOYSA-N

LogP

4.374260000000003

Topological Polar Surface Area

84.85999999999999 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

681

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Troglitazone
(+/-)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione
5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
CS-045
[14C]-Troglitazone
[3H]-Troglitazone
5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methy
5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]-2,4-dioxothiazolidine
5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)-benzyl]thiazolidine-2,4-dione
5-[4-[(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]-benzyl]-2,4-thiazolidinedione
Noscal
Prelay
Rezulin
Rezulin (TN)
Romglizone
Romozin
EPM-426
CS 045
GR 92132X
GR92132X
CI 991
C24H27NO5S
(+-)-all-rac-5-(p-((6-Hydroxy-2,5,7,8-tetramethyl-2-chromanyl)methoxy)benzyl)-2,4-thiazolidinedione
5-(4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolidine-2,4-dione
CS045
GXPHKUHSUJUWKP-UHFFFAOYSA-N
DSSTox_CID_3719
DSSTox_RID_77162
DSSTox_GSID_23719
2,4-Thiazoli
5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione (ACI)

MDL Number

MFCD00878416

FAQ

What regulatory guidelines apply to Troglitazone (CAS: 97322-87-7)?

Troglitazone (CAS: 97322-87-7) is subject to regulatory guidelines under the Globally Harmonized System (GHS) for classification and labeling of chemicals. In Europe, it is regulated under the REACH regulations. In the United States, the Food and Drug Administration (FDA) and Environmental Protection Agency (EPA) have specific requirements for its handling, storage, and disposal.

Are there alternatives to Troglitazone (CAS: 97322-87-7) in synthesis?

Yes, there are alternatives to Troglitazone (CAS: 97322-87-7) in synthesis, such as other thiazolidinediones like pioglitazone. Isomers and analogs can also be explored for similar biological activities. Common alternative reagents include other antidiabetic compounds and structurally related drugs.

What is the market or research trend for Troglitazone (CAS: 97322-87-7)?

The market for Troglitazone (CAS: 97322-87-7) has seen a decline due to safety concerns. However, ongoing research focuses on its potential use in treating non-alcoholic fatty liver disease (NAFLD). The trend is towards developing safer alternatives and understanding the underlying mechanisms of action.

How should waste containing Troglitazone (CAS: 97322-87-7) be handled?

Waste containing Troglitazone (CAS: 97322-87-7) should be collected and stored in leak-proof containers. It should be disposed of through professional waste disposal services that comply with environmental regulations. Proper environmental protection measures, including neutralization if necessary, should be taken to prevent contamination of soil and water sources.