Dapagliflozin Propanediol

Basic Information

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CAS Number

960404-48-2

Molecular Formula

C24H35ClO9

Molecular Weight

502.99 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl.CC(CO)O.O

InChI

InChI=1S/C21H25ClO6.C3H8O2.H2O/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21;1-3(5)2-4;/h3-8,10,17-21,23-26H,2,9,11H2,1H3;3-5H,2H2,1H3;1H2/t17-,18-,19+,20-,21+;3-;/m10./s1

InChIKey

GOADIQFWSVMMRJ-UPGAGZFNSA-N

LogP

0.3791999999999996

Topological Polar Surface Area

171.34 Å²

Hydrogen Bond Donor/Acceptor

8 / 9

Complexity

493

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

DAPAGLIFLOZIN
Dapagliflozin propylene glycolate hydrate
Forxiga
Dapagliflozin (S)-Propylene Glycol Hydrate
Dag column net a water glycol
Dapagliflozin,(2S)-1,2-propanediol, hydrate (1:1:1)
Dapagliflozin ((2S)-1,2-propanediol, hydrate)
Dapagliflozin propanediol hydrate
Dapagliflozin Propanediol Monohydrate
Dapagliflozin propanediol
Farxiga
Dapagliflozin S-propylene glycol monohydrate
Dapagliflozin mixture with propylene glycol, hydrate
887K2391VH
Dapagliflozin [USAN:INN]
Dapagliflozin propylene glycol hydrate
Dapagliflozin propanediol [USAN]
AK322430
dapagliflozin (S)-propylene glycol hy
D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, (1S)-, compd. with (2S)-1,2-propanediol (1:1), monohydrate (9CI)
D
(1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol (S)-propane-1,2-diol (1:1) monohydrate
Dapagliflozin (S)-propylene glycol hydrate
Dapagliflozin propanediol monohydrate
Edistride
DAPAGLIFLOZIN COMPOUND WITH (2S)-1,2-PROPANEDIOL HYDRATE
(2S)-propane-1,2-diol (2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)oxane-3,4,5-triol hydrate
(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, (2S)-propane-1,2-diol (1:1) monohydrate
960404-48-2
DAPAGLIFLOZIN PROPYLENE GLYCOL
AS-64915

MDL Number

MFCD28167768

FAQ

What is Dapagliflozin Propanediol (CAS: 960404-48-2)?

Dapagliflozin Propanediol (CAS: 960404-48-2) is a chemical compound used primarily as a prodrug form of dapagliflozin. It is a white crystalline solid with good solubility in certain solvents. This compound is commonly found in pharmaceutical formulations for its therapeutic properties, particularly in the treatment of type 2 diabetes.

What are the main uses of Dapagliflozin Propanediol (CAS: 960404-48-2)?

Dapagliflozin Propanediol (CAS: 960404-48-2) is mainly used in the pharmaceutical industry as a prodrug for dapagliflozin, which is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It is employed in the development of drugs for managing type 2 diabetes and related metabolic disorders. Additionally, it may be used in research settings for drug formulation and stability studies.

Is Dapagliflozin Propanediol (CAS: 960404-48-2) safe?

Dapagliflozin Propanediol (CAS: 960404-48-2) is generally considered safe when handled according to standard pharmaceutical guidelines. However, it should be used with proper protective measures, such as gloves and eye protection, to avoid skin or eye contact. Safety data sheets and regulatory approvals should be consulted for detailed toxicity information and safe handling practices.

How should Dapagliflozin Propanediol (CAS: 960404-48-2) be stored?

Dapagliflozin Propanediol (CAS: 960404-48-2) should be stored in a cool, dry place away from direct light. It is typically kept in a sealed container at a temperature range of 15-25°C. Proper storage helps maintain its chemical stability and potency. Avoid exposure to moisture and ensure storage conditions comply with pharmaceutical standards.