Eflornithine Hydrochloride

Basic Information

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CAS Number

96020-91-6

Molecular Formula

C6H15ClF2N2O3

Molecular Weight

236.65 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Basic Physical Properties

Melting Point

183°C

Boiling Point

347°Cat760mmHg

Density

1.293

Flash Point

163.7°C

SMILES

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C(CC(C(F)F)(C(=O)O)N)CN.O.Cl

InChI

1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2

InChIKey

FJPAMFNRCFEGSD-UHFFFAOYSA-N

LogP

-0.6304000000000003

Topological Polar Surface Area

120.83999999999999 Å²

Hydrogen Bond Donor/Acceptor

7 / 5

Complexity

166

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

2,5-Diamino-2-(difluoromethyl)pentanoic acid hydrochloride hydrate
2,5-diamino-2-(difluoromethyl)pentanoic acid
DFMO EFLORNITHINE
H-alpha-Difluoro-Me-DL-Orn-OH . HCl . H2O
Eflornithine Hydrochloride Monohydrate
DL-α-Difluoromethylornithine (hydrochloride hydrate)
2,5-diamino-2-(difluoromethyl)pentanoic acid,hydrate,hydrochloride
DIFLUOROMETHYLORNITHINE HCL MONOHYDRATE(RG)
DIGITONIN(RG)
DL-α-Difluoromethylornithine hydrochloride hydrate
Eflornithine (hydrochloride, hydrate)
Eflornithine HCl
Eflornithine hydrochloride hydrate
H-α-Difluoro-Me-DL-Orn-OH · HCl · H₂O
H-α-Difluoro-Me-DL-Orn-OH·HCl·H?O
DFMO hydrochloride hydrate
DMFO HCl
MDL-71782 hydrochloride hydrate
RMI-71782 hydrochloride hydrate
α-difluoromethylornithine hydrochloride hydrate
2-(Difluoromethyl)-DL-ornithine monohydrochloride monohydrate
Eflornithin monohydrochloride monohydrate
DL-α-Difluoromethylornithine Hydrochloride Monohydrate
2-(Difluoromethyl)ornithine hydrochloride hydrate
Eflornithinehydrochloridehydrate
DL-Ornithine, 2-(difluoromethyl)-, monohydrochloride, monohydrate (ZCI)
DL
Ornithine, 2-(difluoromethyl)-, monohydrochloride, monohydrate (9CI)
2,5-Diamino-2-(difluoromethyl)pentanoic acid hydrate hydrochloride
Vaniqa
CCG-266847

MDL Number

MFCD00242734

Customs Code

2922499990

FAQ

What is Eflornithine Hydrochloride (CAS: 96020-91-6)?

Eflornithine Hydrochloride (CAS: 96020-91-6) is a pharmaceutical compound used primarily as an antiparasitic agent. Its chemical formula is C12H15N5O2·HCl, and it appears as a white crystalline powder. It is known for its enzyme-inhibiting properties, targeting ornithine decarboxylase, which makes it effective against African trypanosomiasis.

What are the main uses of Eflornithine Hydrochloride (CAS: 96020-91-6)?

Eflornithine Hydrochloride (CAS: 96020-91-6) is mainly used in pharmaceuticals to treat African sleeping sickness caused by Trypanosoma brucei. It also serves as a research tool for studying enzyme pathways and has potential applications in antifungal and anti-cancer therapies. Its use extends to veterinary medicine for parasitic infections.

Is Eflornithine Hydrochloride (CAS: 96020-91-6) safe?

Eflornithine Hydrochloride (CAS: 96020-91-6) is generally safe when used as directed, but it requires proper handling to minimize risks. It has low toxicity in therapeutic doses, though skin irritation or allergic reactions may occur. Safety standards emphasize using protective gloves, avoiding inhalation, and following ICH guidelines for pharmaceutical applications.

How should Eflornithine Hydrochloride (CAS: 96020-91-6) be stored?

Eflornithine Hydrochloride (CAS: 96020-91-6) should be stored in a cool, dry place (15-30°C), protected from light and moisture. Keep in an airtight container or desiccator to maintain stability. Proper storage ensures its potency and safety, as exposure to humidity or high temperatures may degrade the compound.