Marfey's reagent

Basic Information

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CAS Number

95713-52-3

Molecular Formula

C9H9FN4O5

Molecular Weight

272.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

229 °C

Solubility

acetone: 10 mg/mL, clear, yellow

SMILES

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CC(C(=O)N)NC1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])F

InChI

InChI=1S/C9H9FN4O5/c1-4(9(11)15)12-6-2-5(10)7(13(16)17)3-8(6)14(18)19/h2-4,12H,1H3,(H2,11,15)/t4-/m0/s1

InChIKey

NEPLBHLFDJOJGP-BYPYZUCNSA-N

LogP

2.74750

Complexity

382

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(S)-2-((5-Fluoro-2,4-dinitrophenyl)amino)propanamide
Nalpha-(5-Fluoro-2,4-dinitrophenyl)-L-alaninamide [HPLC Labeling Reagent for e.e. Determination]
N-alpha-(2,4-Dinitro-5-fluorophenyl)-L-alaninamide
(2S)-2-(5-fluoro-2,4-dinitroanilino)propanamide
(S)-2-((5-Fluoro-2,4-dinitrophenyl)-amino)propanamide
MARFEY'S REAGENT
Marfey's reagent
NALPHA-(2,4-DINITRO-5-FLUOROPHENYL)-L-ALANINAMIDE [HPLC LABELING REAGENT FOR E.E. DETERMINATION]
Nα-(2,4-Dinitro-5-fluorophenyl)-L-alaninamide
Propanamide,2-[(5-fluoro-2,4-dinitrophenyl)amino]-, (2S)-
1-FD-AA
FDAA
Nα-(5-Fluoro-2,4-dinitrophenyl)-L-alaninamide
(2S)-2-[(5-Fluoro-2,4-dinitrophenyl)amino]propanamide (ACI)
Propanamide, 2-[(5-fluoro-2,4-dinitrophenyl)amino]-, (S)- (ZCI)
1-Fluoro-2,4-dinitrophenyl-5-L-alaninamide
L
1-Fluoro-2,4-dinitrophenyl-5-L-alanine amide
L-Marfey
Marfey's reagent
Reagents, Marfey's
(2S)-2-[(5-fluoro-2,4-dinitrophenyl)amino]propanamide
EN300-333433
BBL102906
n2-(5-fluoro-2,4-dinitrophenyl)-l-alanine amide
D2259
AC-27851
Nalpha-(2,4-Dinitro-5-fluorophenyl)-L-alaninamide
N-(2,4-Dinitro-5-fluorophenyl)-L-alaninamide
STL556715
C9H9FN4O5

MDL Number

MFCD00042049

Customs Code

2924299090

FAQ

What is Marfey's reagent (CAS: 95713-52-3)?

Marfey's reagent, with the CAS number 95713-52-3, is a chemical compound commonly used in the analysis of amino acids. It is a mixture of 1-fluoro-2,4-dinitrobenzene (FDNB) and a suitable solvent, typically methanol. This reagent is known for its ability to form phenylthiohydantoin derivatives, which are useful in determining the stereochemistry of amino acids through chromatographic analysis.

What are the main uses of Marfey's reagent (CAS: 95713-52-3)?

Marfey's reagent is primarily used in pharmaceutical and biochemical research for the analysis of amino acid sequences. It is also applied in food science to detect protein purity and in industrial quality control to assess the composition of amino acid-based products. Its utility in identifying amino acid stereochemistry makes it a key tool in analytical chemistry.

Is Marfey's reagent (CAS: 95713-52-3) safe?

Marfey's reagent is generally considered safe when handled properly, but it contains potentially hazardous components such as 1-fluoro-2,4-dinitrobenzene. Users should wear appropriate personal protective equipment (PPE), including gloves and goggles, and work in a well-ventilated area. It is classified as a toxic substance, so adherence to safety standards and regulations is essential during its use and disposal.

How should Marfey's reagent (CAS: 95713-52-3) be stored?

Marfey's reagent should be stored in a cool, dry, and dark place, preferably at temperatures below 25°C. It is sensitive to moisture and light, so it should be kept in airtight containers and protected from exposure. Proper labeling and storage in a chemical storage cabinet are recommended to ensure stability and safety.