(3R,5S)-Fluvastatin

Basic Information

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CAS Number

93957-54-1

Molecular Formula

C24H26FNO4

Molecular Weight

411.47 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

681.8℃/760mmHg

SMILES

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CC(C)N1C2=CC=CC=C2C(=C1C=CC(CC(CC(=O)O)O)O)C3=CC=C(C=C3)F

InChI

InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m1/s1

InChIKey

FJLGEFLZQAZZCD-MCBHFWOFSA-N

LogP

4.628100000000006

Topological Polar Surface Area

82.69 Å²

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

590

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H412 Harmful to aquatic life with long lasting effects
Hazardous to the aquatic environment, long-term hazard

Synonyms & References

English

Fluvastatin
7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-2-yl)-3,5-dihydroxy-6-heptenoic acid
Methyl-(±)-(E)-7-[3’-(4’-fluoro-phenyl )-1’-(1’-methylethyl)indol-2’-yl]-3,5- dihydroxy-6- heptenoate
(3R,5S,E)-7-(3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid
6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, (3R,5S,6E)-rel-
FLUVASTATIN NA
FLUVASTATIN SODIUM
Lescol
Lipaxan
Primexin
6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, [R*,S*-(E)]-(±)- (ZCI)
rel-(3R,5S,6E)-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid (ACI)
6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, [R*,S*-(E)]-
Fluvastatin XL
Leschol
NSC 758896
fluvastatin
SCHEMBL2846
6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, (3R,5S,6E)-
NC00659
BRD-K66296774-236-11-3
CS-0019897
(E,3R,5S)-7-[3-(4-fluorophenyl)-1-isopropyl-indol-2-yl]-3,5-dihydroxy-hept-6-enoic acid
Q417942
Prestwick2_000859
EN300-21702553
(3R,5S,6E)-rel-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid
SCHEMBL556754
DTXSID201020962
BRD-K66296774-001-02-0
(+)-(3R,5S)-fluvastatin

MDL Number

MFCD00869941

FAQ

What regulatory guidelines apply to (3R,5S)-Fluvastatin (CAS: 93957-54-1)?

Regulatory guidelines for (3R,5S)-Fluvastatin (CAS: 93957-54-1) include GHS classification as a chemical substance, REACH regulations for its use in the European Union, and FDA/EPA requirements for its production, distribution, and use in the United States. It is also subject to local and national regulations depending on the country of use.

Are there alternatives to (3R,5S)-Fluvastatin (CAS: 93957-54-1) in synthesis?

There are several alternatives to (3R,5S)-Fluvastatin (CAS: 93957-54-1) in synthesis, such as using other statins like simvastatin or lovastatin. Common alternative reagents include different chiral auxiliary systems or enantioselective catalysts to achieve the desired stereochemistry.

What is the market or research trend for (3R,5S)-Fluvastatin (CAS: 93957-54-1)?

The market for (3R,5S)-Fluvastatin (CAS: 93957-54-1) is stable, with ongoing research focusing on its cardiovascular benefits and potential in combination therapies. Recent trends include cost reduction and the development of more sustainable manufacturing processes.

How should waste containing (3R,5S)-Fluvastatin (CAS: 93957-54-1) be handled?

Waste containing (3R,5S)-Fluvastatin (CAS: 93957-54-1) should be collected in appropriate containers and disposed of through professional waste disposal services. Incineration is a common method, and environmental protection precautions such as neutralization of acids or bases should be taken to minimize environmental impact.