(2R)-Amino(4-fluorophenyl)acetic acid

Basic Information

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CAS Number

93939-74-3

Molecular Formula

C8H8FNO2

Molecular Weight

169.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

≥300 °C

Boiling Point

289.9℃ at 760mmHg

Density

1.2345 (estimate)

Flash Point

129.1℃

Specific Rotation

-130° ~ -140° (c=1, 1M HCl)

SMILES

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C1=CC(=CC=C1C(C(=O)O)N)F

InChI

InChI=1S/C8H8FNO2/c9-6-3-1-5(2-4-6)7(10)8(11)12/h1-4,7H,10H2,(H,11,12)/t7-/m1/s1

InChIKey

JKFYKCYQEWQPTM-SSDOTTSWSA-N

LogP

0.9101000000000001

Topological Polar Surface Area

63.31999999999999 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

166

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

d-(4-fluorophenyl) glycine
d(-)-4-fluorophenylglycine
Benzeneacetic acid,alpha-amino-4-fluoro-,(-alphaR)
AS-15899
4-fluoro-d-a-phenylglycine
(2R)-2-amino-2-(4-fluorophenyl)acetic acid
H-D-Phg(4-F)-OH
MFCD00042727
F0863
4-Fluoro-D- alpha -phenylglycine
PD197220
AKOS015853837
EINECS 300-363-8
p-fluorophenylglycine
(r)-amino-(4-fluoro-phenyl)-acetic acid
4-FLUORO-D-2-PHENYLGLYCINE
AC-19554
d-(4-fluorophenyl)glycine
(r)-(-)-4-(fluorophenyl)glycine
D-4-Fluorophenylglycine
JKFYKCYQEWQPTM-SSDOTTSWSA-N
AM9510
DTXSID00917028
(R)-4-Fluorophenylglycine
SCHEMBL205545
(2R)-2-azaniumyl-2-(4-fluorophenyl)acetate
(r)-2-amino-2-(4-fluorophenyl)acetic acid
CS-0043796
AKOS006238374
93939-74-3
4-fluorophenylglycine

MDL Number

MFCD00042727

Customs Code

2922499990

FAQ

What are the physical and chemical properties of (2R)-Amino(4-fluorophenyl)acetic acid (CAS: 93939-74-3)?

(2R)-Amino(4-fluorophenyl)acetic acid has a crystalline form with a molecular weight of approximately 189.11 g/mol. It has a solubility of 3.1 g/L in water at 25°C. This compound is relatively stable under normal conditions but can react with strong bases. It is not flammable and has a low reactivity with common reagents.

How is (2R)-Amino(4-fluorophenyl)acetic acid (CAS: 93939-74-3) typically synthesized?

(2R)-Amino(4-fluorophenyl)acetic acid can be synthesized through a multistep process involving the protection of the amino group, followed by coupling with 4-fluorophenol, and finally deprotection of the amino group. The synthesis typically yields over 90% purity and requires careful control of reaction conditions to achieve high selectivity and yield.

What industries use (2R)-Amino(4-fluorophenyl)acetic acid (CAS: 93939-74-3)?

(2R)-Amino(4-fluorophenyl)acetic acid is primarily used in the pharmaceutical industry as a precursor for drug synthesis. It also finds applications in the polymer industry for the development of functional polymers, and in the production of sensors for detecting specific chemicals. Additionally, it can be used in semiconductor manufacturing as a dopant.

What precautions should be taken when handling (2R)-Amino(4-fluorophenyl)acetic acid (CAS: 93939-74-3)?

When handling (2R)-Amino(4-fluorophenyl)acetic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, lab coat, and safety goggles. Ensure that the work is done in a well-ventilated area or a fume hood. Spills should be cleaned up immediately with appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.