4-Hydroxyphenylglycine

Basic Information

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CAS Number

938-97-6

Molecular Formula

C8H9NO3

Molecular Weight

167.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

235-238°C

Boiling Point

446.3℃ at 760 mmHg

Density

1.41

Refractive Index

1.54

Specific Rotation

-158.4° (c=1, 1mol/L HCl)

SMILES

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C1=CC(=CC=C1C(C(=O)O)N)O

InChI

InChI=1S/C8H9NO3/c9-7(8(11)12)5-1-3-6(10)4-2-5/h1-4,7,10H,9H2,(H,11,12)

InChIKey

LJCWONGJFPCTTL-UHFFFAOYSA-N

LogP

0.4766

Topological Polar Surface Area

83.55000000000001 Å²

Hydrogen Bond Donor/Acceptor

4 / 4

Complexity

164

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

2-Amino-2-(4-hydroxyphenyl)acetic acid
AMINO-(4-HYDROXY-PHENYL)-ACETIC ACID
4-HYDROXY-DL-PHENYLGLYCINE
4-hydroxyphenylglycine
Amino-4-hydroxybenzeneacetic acid
DL-4-OH-Phg-OH
(4-Hydroxyphenyl)(amino)acetic acid
(4-Hydroxyphenyl)glycine
2-(4-Hydroxyphenyl)glycine
DL-4-HYDROXYPHENYLGLYCINE
P-HYDROXY PHENYLGLYCINE
Glycine,2-(p-hydroxyphenyl)- (6CI,7CI,8CI)
(RS)-2-(4-Hydroxyphenyl)glycine
(?à)-2-(4-Hydroxyphenyl)glycine
(?à)-2-(p-Hydroxyphenyl)glycine
(?à)-Amino(p-hydroxyphenyl)aceticacid
(?à)-p-Hydroxyphenylglycine
(?à)-a-Amino-4-hydroxybenzeneacetic acid
DL-2-(4-Hydroxyphenyl)glycine
DL-2-(p-Hydroxyphenyl)glycine
DL-p-Hydroxyphenylglycine
DL-a-Amino(4-hydroxyphenyl)acetic acid
NSC 30081
a-(4-Hydroxyphenyl)glycine
a-(p-Hydroxyphenyl)glycine
a-Amino-p-hydroxyphenylacetic acid
Amino(4-hydroxyphenyl)acetic acid
alpha-Amino-4-hydroxybenzeneacetic acid
(1)-4-Hydroxyphenylglycine
(+/-)-alpha-Amino-4-hydroxybenzeneacetic acid
LJCWONGJFPCTTL-UHFFFAOYSA-N

MDL Number

MFCD00065931

Customs Code

2922501000

FAQ

What are the physical and chemical properties of 4-Hydroxyphenylglycine (CAS: 938-97-6)?

4-Hydroxyphenylglycine (CAS: 938-97-6) is a white crystalline solid with a molecular weight of approximately 188.19 g/mol. It is slightly soluble in water and more soluble in organic solvents like methanol and ethanol. It shows moderate reactivity towards strong bases and can undergo amide formation under basic conditions.

How is 4-Hydroxyphenylglycine (CAS: 938-97-6) typically synthesized?

4-Hydroxyphenylglycine (CAS: 938-97-6) is typically synthesized through the condensation of 4-hydroxybenzaldehyde with glycine. This reaction can be catalyzed by acid or base, leading to a yield of around 90%, with good selectivity towards the desired product.

What industries use 4-Hydroxyphenylglycine (CAS: 938-97-6)?

4-Hydroxyphenylglycine (CAS: 938-97-6) is used in the pharmaceutical industry for the synthesis of certain drugs and in the food industry as a flavor enhancer. It is also utilized in the polymer industry for the development of special polymers and in the sensor industry for its sensing properties.

What precautions should be taken when handling 4-Hydroxyphenylglycine (CAS: 938-97-6)?

When handling 4-Hydroxyphenylglycine (CAS: 938-97-6), it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. It is advisable to conduct operations in a well-ventilated area or a fume hood. In case of spills, immediately clean up with absorbent paper and dispose of the waste according to the safety data sheet (SDS) guidelines.