Sacubitril/Valsartan

Basic Information

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CAS Number

936623-90-4

Molecular Formula

C48H58N6O8

Molecular Weight

847.03 g/mol

EINECS

000-000-0

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

Not available

Boiling Point

Not available

Density

Not available

Flash Point

Not available

Vapor Pressure

Not available

SMILES

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CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)[C@H](C(=O)O)C(C)C.CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)O

InChI

InChI=1S/C24H29N5O3.C24H29NO5/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23;1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28);4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t22-;17-,21+/m01/s1

InChIKey

XTKIDERFOUYBDE-QEPKIHTBSA-N

LogP

7.996700000000008

Topological Polar Surface Area

204.76999999999998 Å²

Hydrogen Bond Donor/Acceptor

4 / 14

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Entresto
LZC696
[(C24H29N5O3).(C24H29NO5).2.5(H2O).3Na]
LCZ696 ENTRESTO TM
LCZ696 Entresto
4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate
Sacubitril mixture with Valsartan
Cocrystal of Sacubitril and Valsartan
Sacubitril
3-(1-Biphenyl-4-ylMethyl-3-ethoxycarbonyl-1-butylcarbaMoyl)propionate-3'-Methyl-2'-(pentanoyl(2'-(tetrazol-5-ylate)biphenyl-4'-ylMethyl)aMino)butyrate
(S)-2-(N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)hexanamido)-3-methylbutanoic acid compound with 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-me
Entresto(LCZ696)
L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, compd. with α-ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl[1,1'-biphenyl]
LCZ 696
LCZ-696
LCZ696 Entresto TM
Valsartan
BAL-4815
Isavuconazole
L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, compd. with α-ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl[1,1'-biphenyl]-4-pentanoate, sodium salt, hydrate (2:2:6:5)
RO-0094815
trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3-methyl-2-(pentanoyl{2”-(tetrazol-5-ylate)biphenyl-4-ylmethyl}amino)butyrate] hemipentahydrate
trisodium 3-((1S,3R)-1-(biphenyl-4-ylme
Sacubitril valsartan sodium hydrate
LCZ696
Sacubitril/Valsartan
Neparvis
Sacubitril-valsartan
Sacubitril-valsartan mixt.
Valsartan sacubitril

MDL Number

MFCD29477717

EC Number

000-000-0

FAQ

What is Sacubitril/Valsartan (CAS: 936623-90-4)?

Sacubitril/Valsartan is a combination medication used primarily in the treatment of heart failure. It contains two active ingredients: sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker. The CAS number 936623-90-4 identifies this specific compound, which is known for its dual mechanism of action in managing cardiovascular conditions.

What are the main uses of Sacubitril/Valsartan (CAS: 936623-90-4)?

Sacubitril/Valsartan (CAS: 936623-90-4) is mainly used to treat heart failure, particularly in patients who have reduced left ventricular ejection fraction. It helps improve heart function and reduce the risk of hospitalization. Additionally, it may be used for other cardiovascular conditions under medical supervision.

Is Sacubitril/Valsartan (CAS: 936623-90-4) safe?

Sacubitril/Valsartan (CAS: 936623-90-4) is generally considered safe when used as directed by a healthcare professional. However, like all medications, it may cause side effects such as dizziness, cough, or hyperkalemia. Proper handling and adherence to safety guidelines are essential to ensure its safe use and minimize risks.

How should Sacubitril/Valsartan (CAS: 936623-90-4) be stored?

Sacubitril/Valsartan (CAS: 936623-90-4) should be stored in a cool, dry place away from moisture and light. It is typically kept at room temperature (15-30°C) and should not be exposed to extreme temperatures. Always store the medication in its original container to maintain stability and effectiveness.