2-Chloro-4-fluoronicotinic acid(CAS: 929022-76-4)

2-Chloro-4-fluoronicotinic acid is a crystalline solid with a molecular weight of approximately 182.02 g/mol. It has a low solubility in water (0.207 g/100 mL at 20°C) and is less reactive than its parent compound nicotinic acid. The compound is stable under normal conditions but may react with strong bases or oxidizing agents.

2-Chloro-4-fluoronicotinic acid is typically synthesized by the reaction of 4-fluoronicotinic acid with thionyl chloride. The process involves the chlorination of the primary amine group at the 2-position. The reaction is carried out in the presence of a solvent such as dichloromethane, and can achieve a yield of up to 85%.

2-Chloro-4-fluoronicotinic acid is used in pharmaceuticals for the synthesis of certain drug candidates. It also finds applications in the development of sensors and is explored in the field of materials science for its potential use in polymer research.

When handling 2-Chloro-4-fluoronicotinic acid, appropriate personal protective equipment (PPE) such as gloves and goggles should be worn. The compound should be stored in a cool, dry place away from heat sources and strong acids. In case of a spill, it should be cleaned up using appropriate absorbent materials and the incident should be reported to the laboratory safety officer. Safety data sheets (SDS) should be consulted for detailed information on handling and emergency procedures.