Raf-265 | CAS No. 927880-90-8

Raf-265

Basic Information

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CAS Number

927880-90-8

Molecular Formula

C24H16F6N6O

Molecular Weight

518.41 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

667.6±65.0°C at 760 mmHg

Density

1.50

SMILES

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CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F

InChI

InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34)

InChIKey

YABJJWZLRMPFSI-UHFFFAOYSA-N

LogP

6.931900000000004

Topological Polar Surface Area

80.65 Å²

Hydrogen Bond Donor/Acceptor

2 / 7

Complexity

763

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Sensitiveness

Light Sensitive

Synonyms & References

English

RAF 265
RAF265 (CHIR-265)
1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]-oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine
1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-Benzimidazol-2-amine
1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine
,CHIR-265,,CHIR265
{1-methyl-5-[2-(5-trifluoromethyl-1H-imidazol-2-yl)-pyridin-4-yIoxy]-1H-benzoimidazol-2-yl}-(4-trifluoromethyl-phenyl)amine
{1-Methyl-5-[2-(5-trifluoromethyl-1H-imidazol-2-yl)-pyridin-4-yloxy]-1H-benzoimidazol-2-yl}-(4-trifluoromethylphenyl)-amine
1-methyl-5-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)-N-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-2-amine
CHIR265
CHIR-265
RAF-265
RAF265
CHIR 265
8O434L3768
1-Methyl-5-({2-[5-(Trifluoromethyl)-1h-Imidazol-2-Yl]pyridin-4-Yl}oxy)-N-[4-(Trifluoromethyl)phenyl]-1h-Benzimidazol-2-Amine
PubChem2
Raf265(chir-265)
1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine (ACI)
1-Methyl-5-([2-[4-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy)-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine
1-Methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine
[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine
1-methyl-5-[2-(5-trifluoromethyl-1H-imidazol-2-yl)pyridin-4-yloxy]-N-(4-trifluoromethylphenyl)-1H-benzo[d]imidazol-2-amine
HMS3672I21
1-methyl-5-({2-[4-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy)-N-[4-(trifluoromethyl)phenyl]-1H-1,3-benzodiazol-2-amine
Q27075961
RAF-265 (CHIR-265)
CHEBI:91451
SW219923-1
1-methyl-5-({2-[4-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy)-N-[4-(trifluoromethyl)phenyl]-1,3-benzodiazol-2-amine
NSC754357

MDL Number

MFCD16659061

FAQ

What is Raf-265 (CAS: 927880-90-8)?

Raf-265 (CAS: 927880-90-8) is a novel histone deacetylase inhibitor used in research for its potential anti-cancer properties. It is a complex organic compound with a unique molecular structure designed to target specific cellular pathways.

What are the main uses of Raf-265 (CAS: 927880-90-8)?

Raf-265 (CAS: 927880-90-8) is primarily used in pharmaceutical research to inhibit histone deacetylases, which play a crucial role in gene expression. It is also explored for its potential anti-cancer effects.

Is Raf-265 (CAS: 927880-90-8) safe?

Raf-265 (CAS: 927880-90-8) is safe when used under controlled laboratory conditions with appropriate handling and protective measures. Users should follow all safety guidelines and precautions to minimize any risks.

How should Raf-265 (CAS: 927880-90-8) be stored?

Raf-265 (CAS: 927880-90-8) should be stored in a cool, dry place away from direct sunlight. It should be kept in a tightly sealed container to protect it from moisture and ensure its stability. Storage at temperatures below 25°C is recommended to maintain its efficacy.