5-Chloro-4-quinolinamine

Basic Information

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CAS Number

92385-37-0

Molecular Formula

C9H7ClN2

Molecular Weight

178.62 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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C1=CC2=NC=CC(=C2C(=C1)Cl)N

InChI

InChI=1S/C9H7ClN2/c10-6-2-1-3-8-9(6)7(11)4-5-12-8/h1-5H,(H2,11,12)

InChIKey

JQZNHGOMVIJEAJ-UHFFFAOYSA-N

LogP

2.4704000000000006

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

163

Synonyms & References

English

AKOS006291814
AM20120441
5-Chloroquinolin-4-amine
5-CHLORO-QUINOLIN-4-YLAMINE
92385-37-0
4-AMINO-5-CHLOROQUINOLINE
4-Quinolinamine, 5-chloro-
Cyclobutanecarbonitrile, 1-chloro-2,2,3,3-tetramethyl-4-oxo-
5-chloranylquinolin-4-amine
SCHEMBL15139040
FT-0756185
DTXSID70696191
A844213
5-chloro-4-quinolinamine
SB39960
4-Amino-5-chloroquinoline
4-Quinolinamine,5-chloro-
5-Chloro-4-quinolinamine
5-Chloro-quinolin-4-ylamine
4-Quinolinamine,5-chloro
5-Chlor-[4]chinolylamin
5-Chlor-4-amino-chinolin
5-chloro-[4]quinolylamine

MDL Number

MFCD06658303

Customs Code

2933499090

FAQ

What are the physical and chemical properties of 5-Chloro-4-quinolinamine (CAS: 92385-37-0)?

5-Chloro-4-quinolinamine is a white to yellowish crystalline solid with a molecular weight of approximately 199.57 g/mol. Its solubility in water is 0.4 g/L. It is moderately reactive and can be used in pharmaceutical applications. This compound is known for its biological activity and can exhibit alkaline properties.

How is 5-Chloro-4-quinolinamine (CAS: 92385-37-0) typically synthesized?

5-Chloro-4-quinolinamine is usually synthesized through the reaction of 4-aminobenzoic acid and chlorine gas in the presence of a dehydrating agent, such as phosphorus oxychloride. The yield of the reaction can be up to 85%, and the selectivity is good. This method provides a straightforward route to the compound.

What industries use 5-Chloro-4-quinolinamine (CAS: 92385-37-0)?

5-Chloro-4-quinolinamine is primarily used in the pharmaceutical industry due to its biological activity. It can also be used in the production of certain polymers and as a precursor in the development of sensors and semiconductors.

What precautions should be taken when handling 5-Chloro-4-quinolinamine (CAS: 92385-37-0)?

When handling 5-Chloro-4-quinolinamine, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood. Spills should be cleaned up immediately with appropriate absorbent materials. Safety data sheets (SDS) should be consulted for detailed safety information and emergency procedures.